Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor

被引：93

作者：

Fishman, Paul S. ^{[1
]}

Elias, W. Jeffrey ^{[2
,3
]}

Ghanouni, Pejman

Gwinn, Ryder ^{[4
]}

Lipsman, Nir ^{[5
]}

Schwartz, Michael

Chang, Jin W. ^{[6
]}

Taira, Takaomi ^{[7
]}

Krishna, Vibhor

Rezai, Ali ^{[8
]}

Yamada, Kazumichi

Igase, Keiji ^{[9
]}

Cosgrove, Rees

Kishima, Haruhiko

Kaplitt, Michael G.

Tierney, Travis S. ^{[10
]}

Eisenberg, Howard M. ^{[11
]}

机构：

[1] Univ Maryland Sch Med, Baltimore, MD USA

[2] Univ Virginia Hlth Sci Ctr, Charlottesville, VA USA

[3] Stanford Univ Sch Med, Stanford, CA USA

[4] Swedish Neuroscience Inst, Seattle, WA USA

[5] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[6] Yonsei Univ Coll Med, Seoul, South Korea

[7] Tokyo Womens Med Univ, Tokyo, Japan

[8] Kumamoto Univ Hosp, Kumamoto & Hokuto Hosp, City, Obihiro, Hokkaido, Japan

[9] Washoukai Sadamoto Hosp, City, Matsuyama, Ehime, Japan

[10] Brigham & Womens Hosp, Boston, MA USA

[11] Weil Cornell Sch Med, New York, NY USA

来源：

MOVEMENT DISORDERS | 2018年 / 33卷 / 05期

关键词：

focused ultrasound; MRgFUS; essential tremor; thalamotomy; DBS; DEEP BRAIN-STIMULATION; MOVEMENT-DISORDERS; TRIAL; RADIOSURGERY; MANAGEMENT; SURGERY;

D O I：

10.1002/mds.27401

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Magnetic resonance imaging-guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications of open stereotactic surgery. Objective: To determine the safety profile of magnetic resonance imaging-guided focused ultrasound unilateral thalamotomy for essential tremor, including frequency, and severity of adverse events, including serious adverse events. Methods: Analysis of safety data for magnetic resonance imaging-guided focused ultrasound thalamotomy (186 patients, five studies). Results: Procedure-related serious adverse events were very infrequent (1.6%), without intracerebral hemorrhages or infections. Adverse events were usually transient and were commonly rated as mild (79%) and rarely severe (1%). As previously reported, abnormalities in sensation and balance were the commonest thalamotomy-related adverse events. Conclusion: The overall safety profile of magnetic resonance imaging-guided focused ultrasound thalamotomy supports its role as a new option for patients with medically refractory essential tremor. (c) 2018 International Parkinson and Movement Disorder Society

引用

页码：843 / 847

页数：5

共 24 条

[1] Speech and Language Adverse Effects After Thalamotomy and Deep Brain Stimulation in Patients With Movement Disorders: A Meta-Analysis [J].