Reduction in exhaled nitric oxide immediately after methacholine challenge in asthmatic children

被引：34
作者：
Piacentini, GL
Bodini, A
Peroni, DG
Del Giudice, MM
Costella, S
Boner, AL
机构：
[1] Univ Verona, Pediat Clin, I-37100 Verona, Italy
[2] Univ Naples 2, Pediat Clin, Naples, Italy
[3] Ist Pio XII, Misurina, Belluno, Italy
来源：
THORAX | 2002年 / 57卷 / 09期
关键词：
D O I：
10.1136/thorax.57.9.771
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Background: The measurement of exhaled nitric oxide (NO) has recently been proposed as a useful technique for the evaluation of airway inflammation in asthma. The purpose of this study was to determine the effect of methacholine bronchial provocation on the levels of exhaled NO in asthmatic children. Method: Exhaled NO was measurement immediately before and after methacholine provocation in 51 children with mild to moderate asthma. Results: A significant decrease occurred in the level of exhaled NO (p<0.0001) after methacholine bronchial provocation which was not correlated with the percentage fall in forced expiratory volume in 1 second (FEV1). Conclusions: The methacholine test should not be used immediately before measurement of exhaled NO in children with asthma.
引用
收藏
页码：771 / 773
页数：3
相关论文
共 19 条
[1]   Exhaled nitric oxide: A new lung function test [J].
Barnes, PJ ;
Kharitonov, SA .
THORAX, 1996, 51 (03) :233-237
[2]  
Byrnes CA, 1997, PEDIATR PULM, V24, P312
[3]  
de Gouw H. W. F. M., 1997, European Respiratory Journal Supplement, V10, p158S
[4]   Exhaled nitric oxide following repeated spirometry or repeated plethysmography in healthy individuals [J].
Deykin, A ;
Massaro, AF ;
Coulston, E ;
Drazen, JM ;
Israel, E .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (04) :1237-1240
[5]   Expired nitric oxide after bronchoprovocation and repeated spirometry in patients with asthma [J].
Deykin, A ;
Halpern, O ;
Massaro, AF ;
Drazen, JM ;
Israel, E .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (03) :769-775
[6]  
FREYSCHUSS U, 1984, AM REV RESPIR DIS, V130, P888
[7]   Exhaled nitric oxide during acute changes of airways calibre in asthma [J].
Garnier, P ;
Fajac, I ;
Dessanges, JF ;
DallAvaSantucci, J ;
Lockhart, A ;
DinhXuan, AT .
EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (06) :1134-1138
[8]   BRONCHIAL RESPONSIVENESS TO HISTAMINE OR METHACHOLINE IN ASTHMA - MEASUREMENT AND CLINICAL-SIGNIFICANCE [J].
HARGREAVE, FE ;
RYAN, G ;
THOMSON, NC ;
OBYRNE, PM ;
LATIMER, K ;
JUNIPER, EF ;
DOLOVICH, J .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1981, 68 (05) :347-355
[9]   Exhaled and nasal nitric oxide measurements: Recommendations [J].
Kharitonov, S ;
Alving, K ;
Barnes, PJ .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (07) :1683-1693
[10]   Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract [J].
Kharitonov, SA ;
Chung, KF ;
Evans, D ;
OConnor, BJ ;
Barnes, PJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (06) :1773-1780
12