Animal models of tuberculosis

被引：63

作者：

Young, Douglas ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Mycobacterial Res, London NW7 1AA, England

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 08期

基金：

比尔及梅琳达.盖茨基金会; 英国医学研究理事会; 英国惠康基金;

关键词：

Biomarkers; Diagnostics; Drugs; Tuberculosis; Vaccines; MYCOBACTERIUM-TUBERCULOSIS; MICE; DISEASE; GROWTH;

D O I：

10.1002/eji.200939542

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is a wide range of animal models of tuberculosis; which is fortunate, given that there is a wide range of complex biological phenomena to model. Nonetheless, the inadequacy of animal models is a chronic grievance amongst researchers, often expressed in the conclusion that the mouse is not a good model of human tuberculosis. There clearly are major differences between experimental infection of mice and natural infection of humans, but this overarching dogma is inconducive to fruitful research.

引用

页码：2011 / 2014

页数：4

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