Effect of peroxynitrite on erythrocytes

被引：76
|
作者：
Soszynski, M
Bartosz, G
机构：
[1] Department of Molecular Biophysics, Univ. of Łódź, Łódź
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1996年 / 1291卷 / 02期
关键词：
peroxynitrite; erythrocyte; membrane; glutathione; thiol group; ATPase; free radical;
D O I：
10.1016/0304-4165(96)00052-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities. Membranes exposed to peroxynitrite showed aggregation and nitration of proteins and changes in protein organization detectable with a maleimide spin label.
引用
收藏
页码：107 / 114
页数：8
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