BG-4 from Bitter Gourd (Momordica charantia) Differentially Affects Inflammation In Vitro and In Vivo

被引:14
作者
Nieto-Veloza, Andrea [1 ]
Wang, Zhihong [1 ]
Zhong, Qixin [1 ]
Krishnan, Hari B. [2 ]
Dia, Vermont P. [1 ]
机构
[1] Univ Tennessee, Dept Food Sci, Knoxville, TN 37996 USA
[2] ARS, USDA, Columbia, MO 65211 USA
关键词
BG-4; bitter gourd; colitis; inflammation; macrophages; LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION; NITRIC-OXIDE; ANTIOXIDANT; COLITIS; MELON; MYELOPEROXIDASE; EXTRACTS; INHIBIT;
D O I
10.3390/antiox8060175
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
BG-4 isolated from bitter gourd has been reported for anti-cancer properties. The objective was to evaluate the anti-inflammatory properties of BG-4 in vitro and in vivo. Comparative study of the anti-inflammatory properties of BG-4 in vitro and in vivo was conducted on lipopolysaccharide (LPS)-activated mouse macrophages, and on dextran sodium sulfate (DSS)-induced colitis in mice. BG-4 reduced the production of pro-inflammatory markers in LPS-activated macrophages. On the other hand, intraperitoneal administration of BG-4 in DSS-induced colitis led to colon shortening, elevated neutrophils infiltration and myeloperoxidase activity, presence of blood in the stool, and loss of body weight, with differential systemic and local effects on pro-inflammatory cytokines in vivo. The results demonstrated that BG-4 differentially affected inflammation in vitro and in vivo.
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页数:11
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