Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis

被引：72
作者：
Arung, Enos Tangke [1 ]
Shimizu, Kuniyoshi [1 ]
Kondo, Ryuichiro [1 ]
机构：
[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Higashi Ku, Fukuoka 8128581, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 09期
关键词：
tyrosinase; melanin; antioxidant; artocarpanone; hyperpigmentation; Artocarpus heterophyllus;
D O I：
10.1248/bpb.29.1966
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.
引用
收藏
页码：1966 / 1969
页数：4
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