Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis?

被引：27

作者：

Ciprandi, Giorgio ^{[1
]}

Gallo, Fabio ^{[2
]}

Ricciardolo, Fabio Luigi Massimo ^{[3
]}

Cirillo, Ignazio ^{[4
]}

机构：

[1] IRCCS Azienda Osped Univ San Martino IST, Dept Med, Largo R Benzi 10, IT-16132 Genoa, Italy

[2] Univ Genoa, Dept Hlth, Genoa, Italy

[3] Univ Turin, Dept Clin & Biol Sci, Turin, Italy

[4] Navy Med Serv, La Spezia, Italy

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2017年 / 172卷 / 02期

关键词：

Allergic rhinitis; Exhaled nitric oxide; Lung function; Bronchial hyperreactivity; Phenotype; BRONCHIAL HYPERREACTIVITY; ASTHMA; CHILDREN; IMPACT; HYPERRESPONSIVENESS; IMMUNOTHERAPY; METHACHOLINE; INFLAMMATION; STRATEGIES; EFFICACY;

D O I：

10.1159/000456548

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. Methods: A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Those patients with a high FeNO underwent a 2-year follow-up. Results: Increased FeNO was associated with a significantly longer AR duration, impaired lung function, more severe symptoms, and more frequent bronchial hyperresponsiveness (BHR). At follow-up, 22 out of 82 patients (26.8%) with high FeNO levels (> 50 ppb) developed asthma. Conclusions: AR patients may frequently have high FeNO values, exceeding 50 ppb. This might be associated with an initial impaired lung function, BHR, a perceived worsening of respiratory symptoms, and potential progression to asthma. (C) 2017 S. Karger AG, Basel

引用

页码：99 / 105

页数：7

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