Neurological disorders and inflammatory bowel diseases

被引：55

作者：

Casella, Giovanni ^{[1
]}

Tontini, Gian Eugenio ^{[2
]}

Bassotti, Gabrio ^{[3
]}

Pastorelli, Luca ^{[2
,4
]}

Villanacci, Vincenzo ^{[5
]}

Spina, Luisa

Baldini, Vittorio ^{[1
]}

Vecchi, Maurizio ^{[4
]}

机构：

[1] Desio Hosp, Dept Med, I-20033 Desio, Italy

[2] IRCCS Policlin San Donato, Gastroenterol & Gastrointestinal Endoscopy Unit, I-20097 San Donato Milanese, Italy

[3] Univ Perugia, Sch Med, Dept Med, Gastroenterol Sect, I-06123 Perugia, Italy

[4] Univ Milan, Dept Biomed Sci Hlth, I-20146 Milan, Italy

[5] Spedali Civil Brescia, Inst Pathol, I-25123 Brescia, Italy

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 27期

关键词：

Inflammatory bowel diseases; Crohn's disease; Ulcerative colitis; Extraintestinal manifestations; Neurological disorders; Multiple sclerosis; Progressive multifocal encephalopathy; Demyelinating neuropathies; Cerebrovascular diseases; Side effects; RESTLESS LEGS SYNDROME; HERPES-SIMPLEX ENCEPHALITIS; CENTRAL-NERVOUS-SYSTEM; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; REVERSIBLE ENCEPHALOPATHY SYNDROME; SENSORINEURAL HEARING-LOSS; WHITE-MATTER LESIONS; FACTOR-ALPHA THERAPY; NECROSIS FACTOR-A; QUALITY-OF-LIFE;

D O I：

10.3748/wjg.v20.i27.8764

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Extraintestinal manifestations occur in about one-third of patients living with inflammatory bowel disease (IBD) and may precede the onset of gastrointestinal symptoms by many years. Neurologic disorders associated with IBD are not frequent, being reported in 3% of patients, but they often represent an important cause of morbidity and a relevant diagnostic issue. In addition, the increasing use of immunosuppressant and biological therapies for IBD may also play a pivotal role in the development of neurological disorders of different type and pathogenesis. Hence, we provide a complete and profound review of the main features of neurological complications associated with IBD, with particular reference to those related to drugs and with a specific focus on their clinical presentation and possible pathophysiological mechanisms. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：8764 / 8782

页数：19

共 174 条

[1] Sensorineural hearing loss in patients with inflammatory bowel disease:: A subclinical extraintestinal manifestation [J].