Research Advancements in Porcine Derived Mesenchymal Stem Cells

被引:34
作者
Bharti, Dinesh [1 ]
Shivakumar, Sharath Belame [1 ]
Subbarao, Raghavendra Baregundi [1 ]
Rho, Gyu-Jin [1 ,2 ]
机构
[1] Gyeongsang Natl Univ, Coll Vet Med, OBS Theriogenol & Biotechnol, Jinju 660701, South Korea
[2] Gyeongsang Natl Univ, Life Sci Res Inst, Jinju 660701, South Korea
关键词
Cell therapy; mesenchymal stem cells; multipotency; porcine; IN-VITRO DIFFERENTIATION; BONE-MARROW; STROMAL CELLS; MYOCARDIAL-INFARCTION; CARTILAGE REPAIR; MATRIX CELLS; SWINE MODEL; OSTEOGENIC DIFFERENTIATION; PROGENITOR CELLS; NUCLEAR TRANSFER;
D O I
10.2174/1574888X10666150723145911
中图分类号
Q813 [细胞工程];
学科分类号
摘要
In the present era of stem cell biology, various animals such as Mouse, Bovine, Rabbit and Porcine have been tested for the efficiency of their mesenchymal stem cells (MSCs) before their actual use for stem cell based application in humans. Among them pigs have many similarities to humans in the form of organ size, physiology and their functioning, therefore they have been considered as a valuable model system for in vitro studies and preclinical assessments. Easy assessability, few ethical issues, successful MSC isolation from different origins like bone marrow, skin, umbilical cord blood, Wharton's jelly, endometrium, amniotic fluid and peripheral blood make porcine a good model for stem cell therapy. Porcine derived MSCs (pMSCs) have shown greater in vitro differentiation and transdifferention potential towards mesenchymal lineages and specialized lineages such as cardiomyocytes, neurons, hepatocytes and pancreatic beta cells. Immunomodulatory and low immunogenic profiles as shown by autologous and heterologous MSCs proves them safe and appropriate models for xenotransplantation purposes. Furthermore, tissue engineered stem cell constructs can be of immense importance in relation to various osteochondral defects which are difficult to treat otherwise. Using pMSCs successful treatment of various disorders like Parkinson's disease, cardiac ischemia, hepatic failure, has been reported by many studies. Here, in this review we highlight current research findings in the area of porcine mesenchymal stem cells dealing with their isolation methods, differentiation ability, transplantation applications and their therapeutic potential towards various diseases.
引用
收藏
页码:78 / 93
页数:16
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