Plant-based vaccines: Expression and oral immunogenicity

被引：2
作者：
Mason, HS [1 ]
机构：
[1] Cornell Univ, Boyce Thompson Inst Plant Res, Ithaca, NY 14853 USA
来源：
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT | 2002年 / 38卷 / 03期
关键词：
plant vaccine; transgenic potato; enterotoxic E. coli; Norwalk virus capsid protein; hepatitis B surface antigen; virus-like particle;
D O I：
10.1079/IVP2002294
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The use of plants for production and delivery of vaccine proteins has shown promise in research conducted during the past decade. Genes encoding bacterial and viral antigens are faithfully expressed, processed, and assembled in plant cells to form immunogenic proteins. Studies in animals and humans showed that ingestion of transgenic potato containing vaccine proteins caused production of antigen-specific antibodies in serum and mucosal secretions. Future studies must aim to improve antigen expression and to develop processes to formulate plant material for antigen stability and convenient oral delivery. Furthermore, production methods should ensure the containment of pharmaceutical crops and prevent contamination of the food supply.
引用
收藏
页码：237 / 240
页数：4
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