Plant-based vaccines: Expression and oral immunogenicity

被引：2

作者：

Mason, HS ^{[1
]}

机构：

[1] Cornell Univ, Boyce Thompson Inst Plant Res, Ithaca, NY 14853 USA

来源：

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT | 2002年 / 38卷 / 03期

关键词：

plant vaccine; transgenic potato; enterotoxic E. coli; Norwalk virus capsid protein; hepatitis B surface antigen; virus-like particle;

D O I：

10.1079/IVP2002294

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The use of plants for production and delivery of vaccine proteins has shown promise in research conducted during the past decade. Genes encoding bacterial and viral antigens are faithfully expressed, processed, and assembled in plant cells to form immunogenic proteins. Studies in animals and humans showed that ingestion of transgenic potato containing vaccine proteins caused production of antigen-specific antibodies in serum and mucosal secretions. Future studies must aim to improve antigen expression and to develop processes to formulate plant material for antigen stability and convenient oral delivery. Furthermore, production methods should ensure the containment of pharmaceutical crops and prevent contamination of the food supply.

引用

页码：237 / 240

页数：4

共 50 条

[11] Expression of Rotavirus Capsid Protein VP6 in Transgenic Potato and Its Oral Immunogenicity in Mice [J].

Jie Yu ;

William Langridge .

Transgenic Research, 2003, 12 :163-169

[12] New approaches in oral rotavirus vaccines [J].

Defo, Zenas Kuate ;

Lee, Byong .

CRITICAL REVIEWS IN MICROBIOLOGY, 2016, 42 (03) :495-505

[13] Plant-made trained immunity-based vaccines: Beyond one approach [J].

Monreal-Escalante, Elizabeth ;

Angulo, Miriam ;

Ramos-Vega, Abel ;

Trujillo, Edgar ;

Angulo, Carlos .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2025, 675

[14] Plant-produced Recombinant Influenza A Vaccines Based on the M2e Peptide [J].

Mardanova, Eugenia S. ;

Ravin, Nikolai V. .

CURRENT PHARMACEUTICAL DESIGN, 2018, 24 (12) :1317-1324

[15] Heterologous boosting increases immunogenicity of chimeric papillomavirus virus-like particle vaccines [J].

Da Silva, DA ;

Schiller, JT ;

Kast, WM .

VACCINE, 2003, 21 (23) :3219-3227

[16] Plant-Made Vaccines in the Fight Against Cancer [J].

Wong-Arce, Alejandra ;

Gonzalez-Ortega, Omar ;

Rosales-Mendoza, Sergio .

TRENDS IN BIOTECHNOLOGY, 2017, 35 (03) :241-256

[17] State of research in the field of the creation of plant vaccines for veterinary use [J].

Permyakova, N. V. ;

Uvarova, E. A. ;

Deineko, E. V. .

RUSSIAN JOURNAL OF PLANT PHYSIOLOGY, 2015, 62 (01) :23-38

[18] The Immunogenicity of Capsid-Like Particle Vaccines in Combination with Different Adjuvants Using Different Routes of Administration [J].

Janitzek, Christoph M. ;

Carlsen, Philip H. R. ;

Thrane, Susan ;

Khanna, Vijansh M. ;

Jakob, Virginie ;

Barnier-Quer, Christophe ;

Collin, Nicolas ;

Theander, Thor G. ;

Salanti, Ali ;

Nielsen, Morten A. ;

Sander, Adam F. .

VACCINES, 2021, 9 (02) :1-14

[19] Plant molecular farming of virus-like nanoparticles as vaccines and reagents [J].

Rybicki, Edward P. .

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2020, 12 (02)

[20] Clinical development of plant-produced recombinant pharmaceuticals Vaccines, antibodies and beyond [J].

Yusibov, Vidadi ;

Streatfield, Stephen J. ;

Kushnir, Natasha .

HUMAN VACCINES, 2011, 7 (03) :313-321

← 1 2 3 4 5 →