Rhodium(III)-Catalyzed [4+2] Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides

被引：17

作者：

Song, Xiaohan ^{[1
,2
,3
]}

Han, Xu ^{[1
,2
,3
]}

Zhang, Rui ^{[1
,2
,3
]}

Liu, Hong ^{[1
,2
,3
]}

Wang, Jiang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China

[3] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 10期

基金：

中国国家自然科学基金;

关键词：

rhodium(III); sulfoxonium ylides; naphthols; ADRENERGIC BLOCKING-AGENTS; CATALYZED SYNTHESIS; DIONCOPHYLLINE; FUNCTIONALIZATION; DERIVATIVES; NAPHTHOLS; BOND;

D O I：

10.3390/molecules24101884

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A convenient Rh(III)-catalyzed C-H activation and cascade [4+2] annulation for the synthesis of naphthalenone sulfoxonium ylides has been developed. This method features perfect regioselectivity, mild and redox-neutral reaction conditions, and broad substrate tolerance with good to excellent yields. Preliminary mechanistic experiments were conducted and a plausible reaction mechanism was proposed. The new type naphthalenone sulfoxonium ylides could be further transformed into multi-substituted naphthols, which demonstrates the practical utility of this methodology.

引用

页数：17

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