Rhodium(III)-Catalyzed [4+2] Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides

被引：17
|
作者：
Song, Xiaohan [1 ,2 ,3 ]
Han, Xu [1 ,2 ,3 ]
Zhang, Rui [1 ,2 ,3 ]
Liu, Hong [1 ,2 ,3 ]
Wang, Jiang [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
[3] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
来源：
MOLECULES | 2019年 / 24卷 / 10期
基金：
中国国家自然科学基金;
关键词：
rhodium(III); sulfoxonium ylides; naphthols; ADRENERGIC BLOCKING-AGENTS; CATALYZED SYNTHESIS; DIONCOPHYLLINE; FUNCTIONALIZATION; DERIVATIVES; NAPHTHOLS; BOND;
D O I：
10.3390/molecules24101884
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A convenient Rh(III)-catalyzed C-H activation and cascade [4+2] annulation for the synthesis of naphthalenone sulfoxonium ylides has been developed. This method features perfect regioselectivity, mild and redox-neutral reaction conditions, and broad substrate tolerance with good to excellent yields. Preliminary mechanistic experiments were conducted and a plausible reaction mechanism was proposed. The new type naphthalenone sulfoxonium ylides could be further transformed into multi-substituted naphthols, which demonstrates the practical utility of this methodology.
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收藏
页数：17
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