Serotonin research: Crossing scales and boundaries

被引:11
作者
Di Giovanni, Giuseppe [1 ,2 ]
De Deurwaerdere, Philippe [3 ]
机构
[1] Univ Malta, Fac Med & Surg, Dept Physiol & Biochem, Lab Neurophysiol, Msida, Malta
[2] Cardiff Univ, Sch Biosci, Neurosci Div, Cardiff, Wales
[3] CNRS, UMR 5287, Ctr Natl Rech Sci, Bordeaux, France
关键词
D O I
10.1016/j.neuropharm.2020.108340
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nearly 100 years after the discovery of serotonin, its role remains elusive. Modulation of serotonin transmission is considered in numerous central nervous system (CNS) diseases including depression, anxiety, schizophrenia, obsessive-compulsive disorders, addiction, Parkinson's disease, and Alzheimer's disease. The thera-peutic strategies based on serotonin systems have evolved thanks to better identification of the involvement of serotonin in various diseases, the better use of animal models, a better understanding of the molecular environment of serotonin receptors, and ultimately the better understanding of the interaction of serotonin neurotransmission with other biological systems. Some 5-HT receptors are still the object of numerous investigations including 5-HT1A, 5-HT2A, and 5-HT6 receptor subtypes. It is noteworthy that the direction of research is moving towards a simultaneous action at multiple targets either through different 5-HT targets or the consideration of both 5-HT and other targets to achieve better therapeutic responses.
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页数:4
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