Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice)

被引：36

作者：

Colomeu, T. C. ^{[1
]}

Figueiredo, D. ^{[1
]}

Cazarin, C. B. B. ^{[2
]}

Schumacher, N. S. G. ^{[1
]}

Marostica, M. R., Jr. ^{[2
]}

Meletti, L. M. M. ^{[3
]}

Zollner, R. L. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083887 Campinas, SP, Brazil

[2] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, BR-13083862 Campinas, SP, Brazil

[3] Agron Inst Campinas, BR-13012970 Campinas, SP, Brazil

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 18卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Antioxidant capacity; Passiflora alata Curtis; Glutathione (GSH); Type 1 Diabetes mellitus; Non-obese diabetic mice; PROINFLAMMATORY CYTOKINES; OXIDATIVE STRESS; END-PRODUCTS; EXPRESSION; CONSTITUENTS; POLYPHENOLS; RECEPTOR; ASSAYS;

D O I：

10.1016/j.intimp.2013.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds and antioxidant activity, when compared with methanol/acetone and ethanol. To study the anti-inflammatory properties of this extract in experimental type 1 diabetes, NOD mice were divided into two groups: the P. alata group, treated with aqueous extract of P. alata Curtis, and a non-treated control group, followed by diabetes expression analysis. The consumption of aqueous extract and water ad libitum lasted 28 weeks. The treated-group presented a decrease in diabetes incidence, a low quantity of infiltrative cells in pancreatic islets and increased glutathione in the kidney and liver (p <0.05), when compared with the diabetic and non-diabetic control-groups. In conclusion, our results suggest that the consumption of aqueous extract of P. alata may be considered a good source of natural antioxidants and compounds found in its composition can act as anti-inflammatory agents, helping in the control of diabetes. (C) 2013 Elsevier B.V. All tights reserved.

引用

页码：106 / 115

页数：10

共 42 条

[1]

[Anonymous], 2010, FARMACOPEIA BRASILEI, V2, P546

[2]

Atkinson MA, 2001, LANCET, P358

[3] Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy [J].

Bhatia, S ;

Shukla, R ;

Madhu, SV ;

Gambhir, JK ;

Prabhu, KM .

CLINICAL BIOCHEMISTRY, 2003, 36 (07) :557-562

[4]

Brand-Williams W, 1995, LWT-FOOD SCI TECHNOL, V28, P25

[5]

Chen B, 2012, CROP ENV BIOINFORMAT, V8, P109

[6]

Contreras-Calderon J, 2010, FOOD RES INT, V10, P1

[7] Passiflora:: a review update [J].

Dhawan, K ;

Dhawan, S ;

Sharma, A .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 94 (01) :1-23

[8]

Faure P., 1995, P237

[9] Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice [J].

Filippi, Christophe M. ;

Estes, Elizabeth A. ;

Oldham, Janine E. ;

von Herrath, Matthias G. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1515-1523

[10]

Halliwell B, 1996, ANNU REV NUTR, V16, P33, DOI 10.1146/annurev.nu.16.070196.000341

← 1 2 3 4 5 →