Synthesis and anti-diabetic activity of bis(α-furancarboxylato)oxovanadium(IV)

被引：0
|
作者：
Xie, MJ [1 ]
Liu, WP
Li, L
Chen, ZH
机构：
[1] Kunming Inst Precious Met, Kunming 650221, Peoples R China
[2] Kunming Med Coll, Kunming 650031, Peoples R China
来源：
ACTA CHIMICA SINICA | 2002年 / 60卷 / 05期
关键词：
bis(alpha-furancarboxylato)oxovanadium(B) complex; synthesis; structure; anti-diabetic activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Bis(alpha-furancarboxylato)oxovanadium(IV) was designed and synthesized. Its chemical structure was determined by using elemental analysis, IR, UV, MS and H-1 NMR spectra. This complex was submitted to the test of preliminary toxicity and anti-diabetic activity in mice. The results show that bis(alpha-furancarboxylato)oxovanadium(IV) is safe and can significantly lower the glucose level in blood of mice, exhibiting potential application in treating diabetes.
引用
收藏
页码：892 / 896
页数：5
相关论文
共 10 条
  • [1] VANADIUM COMPLEXES OF TRANSFERRIN AND FERRITIN IN THE RAT
    CHASTEEN, ND
    LORD, EM
    THOMPSON, HJ
    GRADY, JK
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 884 (01) : 84 - 92
  • [2] TOXICITY STUDIES ON ONE-YEAR TREATMENT OF NONDIABETIC AND STREPTOZOTOCIN-DIABETIC RATS WITH VANADYL SULFATE
    DAI, S
    THOMPSON, KH
    VERA, E
    MCNEILL, JH
    [J]. PHARMACOLOGY & TOXICOLOGY, 1994, 75 (05): : 265 - 273
  • [3] Multifunctional actions of vanadium compounds on insulin signaling pathways: Evidence for preferential enhancement of metabolic versus mitogenic effects
    Fantus, IG
    Tsiani, E
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 182 (1-2) : 109 - 119
  • [4] BIS(MALTOLATO)OXOVANADIUM(IV) IS A POTENT INSULIN MIMIC
    MCNEILL, JH
    YUEN, VG
    HOVEYDA, HR
    ORVIG, C
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (08) : 1489 - 1491
  • [5] NIELSEN FH, 1995, MET IONS BIOL SYST, V31, P543
  • [6] ORVIG C, 1995, MET IONS BIOL SYST, V31, P575
  • [7] SONIA M, 1995, TIPE, V16, P265
  • [8] XIE MJ, 2001, CHIN J MED CHEM, V3, P134
  • [9] GLUCOSE-LOWERING EFFECTS OF A NEW ORGANIC VANADIUM COMPLEX, BIS(MALTOLATO)OXOVANADIUM(IV)
    YUEN, VG
    ORVIG, C
    MCNEILL, JH
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1993, 71 (3-4) : 263 - 269
  • [10] ZHANG ZZ, 1995, DEV RES DRUGS, P252
1