Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus

被引：51
作者：
Chiocca, S [1 ]
Baker, A [1 ]
Cotten, M [1 ]
机构：
[1] INST MOL PATHOL,A-1030 VIENNA,AUSTRIA
来源：
JOURNAL OF VIROLOGY | 1997年 / 71卷 / 04期
关键词：
D O I：
10.1128/JVI.71.4.3168-3177.1997
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We have developed a simple screening method to identify genes that mimic bcl-2 or adenovirus E1B 19K in enhancing cell survival after transfection and have used this method to identify such a gene in the avian adenovirus CELO. The gene encodes a novel 30-kDa nuclear protein, which we have named GAM-1, that functions comparably to Bcl-2 and adenovirus E1B 19K in blocking apoptosis. However, GAM-1 has no sequence homology to Bcl-2, E1B 19K, or any other known antiapoptotic proteins and thus defines a novel antiapoptotic function.
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页码：3168 / 3177
页数：10
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