Chemiluminescence detection of isoniazid using Ru(phen)32+-isoniazid-Ce(IV) system

被引：33
作者：
Juan, X
Shi, B
Ai, XP
He, ZK [1 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
[2] Hubei Inst Natl, Dept Chem & Chem Engn, Enshi 445000, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 36卷 / 01期
基金：
中国国家自然科学基金;
关键词：
chemiluminescence; isoniazid; tris-(1,10-phenanthroline)ruthenium(II);
D O I：
10.1016/j.jpba.2004.05.021
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In our experiment, it was observed that isoniazid could enhance the chemiluminescence (CL) emission of tris-(1,10-phenanthroline) ruthenium(II) (Ru(phen)(3)(2+))-cerium(IV) (Ce(IV)) system and this enhancement effect was dependent on the concentration of isoniazid, based on which, a novel CL system was established for the detection of isoniazid. Under the optimum experimental conditions, the dynamic range and detection limit are 7.0 x 10-2 to 6.5 mug ml(-1) and 2.5 x 10-2 mug ml(-1), respectively. The R.S.D. is 3.4% (n = 11). The proposed method has been applied to detect the content of isoniazid in the injection solution with satisfactory results. The possible mechanism of the CL reaction was studied. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：237 / 241
页数：5
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