Diagnostic efficacy of the magnetic resonance T1w/T2w ratio for the middle cerebellar peduncle in multiple system atrophy and spinocerebellar ataxia: A preliminary study

被引：2

作者：

Wang, Jiaqi ^{[1
]}

Sugiyama, Atsuhiko ^{[1
]}

Yokota, Hajime ^{[2
]}

Hirano, Shigeki ^{[1
]}

Cooper, Graham ^{[3
,4
,5
,6
,7
,8
,9
,10
,11
,12
]}

Mukai, Hiroki ^{[13
]}

Ohira, Kenji ^{[13
]}

Koide, Kyosuke ^{[1
]}

Ito, Shoichi ^{[1
,14
]}

Finke, Carsten ^{[9
,12
,15
]}

Brandt, Alexander U. ^{[8
,16
]}

Paul, Friedemann ^{[3
,4
,5
,6
,7
,8
,9
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurol, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Dept Diagnost Radiol & Radiat Oncol, Chiba, Japan

[3] Max Delbrueck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany

[4] Charite Univ Med Berlin, Berlin, Germany

[5] Free Univ Berlin, Berlin, Germany

[6] Humboldt Univ, Berlin, Germany

[7] Berlin Inst Hlth, Berlin, Germany

[8] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[9] Einstein Ctr Neurosci, Berlin, Germany

[10] Charite Univ Med Berlin, Dept Expt Neurol, Berlin, Germany

[11] Charite Univ Med Berlin, Ctr Stroke Res, Berlin, Germany

[12] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[13] Chiba Univ Hosp, Dept Radiol, Chiba, Japan

[14] Chiba Univ, Grad Sch Med, Dept Med Educ, Chiba, Japan

[15] Humboldt Univ, Berlin Sch Mind & Brain, Berlin, Germany

[16] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA

来源：

PLOS ONE | 2022年 / 17卷 / 04期

关键词：

MACHADO-JOSEPH-DISEASE; IMAGING FINDINGS; CLINICAL-FEATURES; T(1)W/T(2)W RATIO; MYELIN CONTENT; CRITERIA; CORTEX; MRI;

D O I：

10.1371/journal.pone.0267024

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundThe standardized T1-weighted/T2-weighted (sT1w/T2w) ratio for the middle cerebellar peduncle (MCP) has been reported to be sensitive for detecting degenerative changes in the cerebellar subtype of multiple system atrophy (MSA-C), even in the early stages. We aimed to investigate the diagnostic value of the MCP sT1w/T2w ratio for differentiating between MSA-C and spinocerebellar ataxia (SCA). MethodsWe included 32 MSA-C, 8 SCA type 3 (SCA3), 16 SCA type 6 (SCA6) patients, and 17 controls, and the MCP sT1w/T2w ratio was analyzed using a region-of-interest approach. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating among MSA-C, SCA3, and SCA6 was assessed and compared with diagnosis based on visual interpretation of MCP hyperintensities and the "hot cross bun" (HCB) sign. ResultsMCP sT1w/T2w ratio values were markedly lower in patients with MSA-C than in those with SCA3, those with SCA6, and controls (p < 0.001). The MCP sT1w/T2w ratio showed high diagnostic accuracy for distinguishing MSA-C from SCA3 (area under curve = 0.934), SCA6 (area under curve = 0.965), and controls (area under curve = 0.980). The diagnostic accuracy of the MCP sT1w/T2w ratio for differentiating MSA-C from SCA3 or SCA6 (90.0% for MSA-C vs. SCA3, and 91.7% for MSA-C vs. SCA6) was comparable to or superior than that of visual interpretation of MCP hyperintensities (80.0-87.5% in MSA-C vs. SCA3 and 87.6-97.9% in MSA-C vs. SCA6) or the HCB sign (72.5-80.0% in MSA-C vs. SCA3 and 77.1-93.8% in MSA-C vs. SCA6). ConclusionsThe MCP sT1w/T2w ratio might be a sensitive imaging-based marker for detecting MSA-C-related changes and differentiating MSA-C from SCA3 or SCA6.

引用

页数：15

共 49 条

[1] Test-Retest Reliability and Concurrent Validity of in Vivo Myelin Content Indices: Myelin Water Fraction and Calibrated T1w/T2w Image Ratio [J].