Regulation of purine nucleotide biosynthesis: in yeast and beyond

被引：48
作者：
Rolfes, R. J. [1 ]
机构：
[1] Georgetown Univ, Dept Biol, Washington, DC 20057 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷
关键词：
adenine; BAS1; PH02; purine nucleotide biosynthesis; transcription; yeast;
D O I：
10.1042/BST0340786
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Purine nucleotides are critically important for the normal functioning of cells due to their myriad of activities. It is important for cells to maintain a balance in the pool sizes of the adenine-containing and guanine-containing nucleotides, which occurs by a combination of de novo synthesis and salvage pathways that interconvert the purine nucleotides. This review describes the mechanism for regulation of the biosynthetic genes in the yeast Saccharomyces cerevisiae and compares this mechanism with that described in several microbial species.
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收藏
页码：786 / 790
页数：5
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