Disappearance of TBEV Circulation among Rodents in a Natural Focus in Alsace, Eastern France

被引:16
作者
Bournez, Laure [1 ]
Umhang, Gerald [1 ]
Moinet, Marie [1 ,7 ]
Boucher, Jean-Marc [1 ]
Demerson, Jean-Michel [1 ]
Caillot, Christophe [1 ]
Legras, Leo [1 ]
Devillers, Elodie [2 ]
Hansmann, Yves [3 ,4 ]
Velay, Aurelie [5 ,6 ]
Richomme, Celine [1 ]
Moutailler, Sara [2 ]
Boue, Franck [1 ]
机构
[1] French Agcy Food Environm & Occupat Hlth & Safety, Nancy Lab Rabies & Wildlife, CS 40009, F-54220 Malzeville, France
[2] Ecole Natl Vet Alfort, INRAE, ANSES, Unite Mixte Rech Biol Mol & Immunol Parasitaire U, F-94700 Maisons Alfort, France
[3] CHU Strasbourg, Dept Malad Infect, F-67000 Strasbourg, France
[4] Univ Strasbourg, Unite Rech 7290, Virulence Bacterienne Precoce Fonct Cellulaires &, F-67000 Strasbourg, France
[5] CHU Strasbourg, Lab Virol, F-67000 Strasbourg, France
[6] Univ Strasbourg, INSERM, Unite Mixte Rech Immunorhumathol Mol UMR IRM S 11, F-67000 Strasbourg, France
[7] AgResearch, Hopkirk Res Inst, Grasslands Res Ctr, Palmerston North 4442, New Zealand
关键词
tick-borne encephalitis virus; Ixodes ricinus; tick; small mammal; seroprevalence; endemic fadeout; TICK-BORNE ENCEPHALITIS; IXODES-RICINUS ACARI; LYME BORRELIOSIS; DEER DENSITY; APODEMUS-FLAVICOLLIS; SATURATION DEFICIT; QUESTING ACTIVITY; IXODIDAE; VIRUS; TRANSMISSION;
D O I
10.3390/pathogens9110930
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Tick-borne encephalitis virus (TBEV) depends mainly on a fragile mode of transmission, the co-feeding between infected nymphs and larvae on rodents, and thus persists under a limited set of biotic and abiotic conditions. If these conditions change, natural TBEV foci might be unstable over time. We conducted a longitudinal study over seven years in a mountain forest in Alsace, Eastern France, located at the western border of known TBEV distribution. The objectives were (i) to monitor the persistence of TBEV circulation between small mammals and ticks and (ii) to discuss the presence of TBEV circulation in relation to the synchronous activity of larvae and nymphs, to the densities of questing nymphs and small mammals, and to potential changes in meteorological conditions and deer densities. Small mammals were trapped five times per year from 2012 to 2018 to collect blood samples and record the presence of feeding ticks, and were then released. Questing nymphs were collected twice a year. Overall, 1344 different small mammals (Myodes glareolus and Apodemus flavicollis) were captured and 2031 serum samples were tested for the presence of antibodies against TBEV using an in-house ELISA. Seropositive rodents (2.1%) were only found from 2012 to 2015, suggesting that the virus disappeared afterwards. In parallel, we observed unusual variations in inter-annual nymph abundance and intra-annual larval activity that could be related to exceptional meteorological conditions. Changes in the densities of questing nymphs and deer associated with the natural stochastic variations in the frequency of contacts between rodents and infected ticks may have contributed to the endemic fadeout of TBEV on the study site. Further studies are needed to assess whether such events occur relatively frequently in the area, which could explain the low human incidence of TBE in Alsace and even in other areas of France.
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页码:1 / 13
页数:13
相关论文
共 43 条
[1]   Rodents as Sentinels for the Prevalence of Tick-Borne Encephalitis Virus [J].
Achazi, Katharina ;
Ruzek, Daniel ;
Donoso-Mantke, Oliver ;
Schlegel, Mathias ;
Ali, Hanan Sheikh ;
Wenk, Mathias ;
Schmidt-Chanasit, Jonas ;
Ohlmeyer, Lutz ;
Ruehe, Ferdinand ;
Vor, Torsten ;
Kiffner, Christian ;
Kallies, Rene ;
Ulrich, Rainer G. ;
Niedrig, Matthias .
VECTOR-BORNE AND ZOONOTIC DISEASES, 2011, 11 (06) :641-647
[2]  
[Anonymous], The R Project for Statistical Computing
[3]   Tick-borne encephalitis in Europe, 2012 to 2016 [J].
Beaute, Julien ;
Spiteri, Gianfranco ;
Warns-Petit, Eva ;
Zeller, Herve .
EUROSURVEILLANCE, 2018, 23 (45) :2-10
[4]   Effect of deer density on tick infestation of rodents and the hazard of tick-borne encephalitis. II: Population and infection models [J].
Bolzoni, L. ;
Rosa, R. ;
Cagnacci, F. ;
Rizzoli, A. .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2012, 42 (04) :373-381
[5]   Tick-Borne Encephalitis Virus: Seasonal and Annual Variation of Epidemiological Parameters Related to Nymph-to-Larva Transmission and Exposure of Small Mammals [J].
Bournez, Laure ;
Umhang, Gerald ;
Moinet, Marie ;
Richomme, Celine ;
Demerson, Jean-Michel ;
Caillot, Christophe ;
Devillers, Elodie ;
Boucher, Jean-Marc ;
Hansmann, Yves ;
Boue, Franck ;
Moutailler, Sara .
PATHOGENS, 2020, 9 (07) :1-19
[6]   Forecasting next season's Ixodes ricinus nymphal density: the example of southern Germany 2018 [J].
Brugger, Katharina ;
Walter, Melanie ;
Chitimia-Dobler, Lidia ;
Dobler, Gerhard ;
Rubel, Franz .
EXPERIMENTAL AND APPLIED ACAROLOGY, 2018, 75 (03) :281-288
[7]   Microclimate and the Zoonotic Cycle of Tick-Borne Encephalitis Virus in Switzerland [J].
Burri, C. ;
Bastic, V. ;
Maeder, G. ;
Patalas, E. ;
Gern, L. .
JOURNAL OF MEDICAL ENTOMOLOGY, 2011, 48 (03) :615-627
[8]   Serological Evidence of Tick-Borne Encephalitis Virus Infection in Rodents Captured at Four Sites in Switzerland [J].
Burri, Caroline ;
Korva, Misa ;
Bastic, Viktoria ;
Knap, Natasa ;
Avsic-Zupanc, Tatjana ;
Gern, Lise .
JOURNAL OF MEDICAL ENTOMOLOGY, 2012, 49 (02) :436-439
[9]   Effects of deer density on tick infestation of rodents and the hazard of tick-borne encephalitis. I: Empirical assessment [J].
Cagnacci, F. ;
Bolzoni, L. ;
Rosa, R. ;
Carpi, G. ;
Hauffe, H. C. ;
Valent, M. ;
Tagliapietra, V. ;
Kazimirova, M. ;
Koci, J. ;
Stanko, M. ;
Lukan, M. ;
Henttonen, H. ;
Rizzoli, A. .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2012, 42 (04) :365-372
[10]   Sense and sensitivity - designing surveys based on an imperfect test [J].
Cannon, RM .
PREVENTIVE VETERINARY MEDICINE, 2001, 49 (3-4) :141-163