Selected blood serum biochemical indicators in twelve inbred strains of laboratory mice

被引：0

作者：

Wirth-Dzieciolowska, Elzbieta ^{[1
,2
,4
]}

Karaszewska, Jadwiga ^{[1
,2
]}

Sadowski, Tomasz ^{[2
,3
]}

Pysniak, Kazimiera ^{[1
,2
]}

Gajewska, Marta ^{[1
,2
]}

机构：

[1] Maria Sklodowska Curie Mem Canc Ctr, Dept Genet & Lab Anim Breeding, PL-02781 Warsaw, Poland

[2] Inst Oncol Warsaw, PL-02781 Warsaw, Poland

[3] Maria Sklodowska Curie Mem Canc Ctr, Dept Clin Chem, PL-02781 Warsaw, Poland

[4] Agr Univ Warsaw, Dept Genet & Anim Breeding, PL-02786 Warsaw, Poland

来源：

ANIMAL SCIENCE PAPERS AND REPORTS | 2009年 / 27卷 / 02期

关键词：

biochemical blood indicators; blood; inbred strains; mice; MOUSE STRAINS; PHENOTYPES;

D O I：

暂无

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

A total of 215 animals of twelve inbred strains of mice (A.CA/W, AKR/W, BALB/cW, BN/aW, C57BL/6W, C57B1/10W, CBA/W, CBAT6/W, C3H/W, DBA/2W, 129SI/SvW and HLB/219J) bred at the Cancer Centre and Institute of Oncology, Warsaw (Oncology Centre), were characterized in terms of five blood serum biochemical indicators related to their health, reproduction and genetic background. Glucose, total protein, creatinine, triglycerides (triacylglycerols) and total cholesterol were determined in mice aged four months. Significant interstrain differences were found among nearly all parameters considered, with the exception of total protein. The level of triglycerides showed wide interstrain differences and revealed a similar variation trend as the total cholesterol. For cholesterol and triglycerides, significant differences between sexes for the majority of strains were found. The results obtained may be important in the selection of experimental animals, for analysis of changes associated with various diseases, and for the explanation of their genetic background.

引用

页码：159 / 167

页数：9