Cognitive Enhancers (Nootropics). Part 1: Drugs interacting with Receptors. Update 2014

被引：18

作者：

Froestl, Wolfgang ^{[1
]}

Muhs, Andreas ^{[1
]}

Pfeifer, Andrea ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, AC Immune SA, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 41卷 / 04期

关键词：

Alzheimer's disease; cognitive enhancers; memantine; memory; nootropics; receptors; NICOTINIC ACETYLCHOLINE-RECEPTOR; POSITIVE ALLOSTERIC MODULATOR; PERIPHERAL BENZODIAZEPINE-RECEPTOR; VORTIOXETINE LU AA21004; GLYCATION END-PRODUCTS; CALCIUM-SENSING RECEPTOR; TRANSGENIC MOUSE MODEL; ALZHEIMERS-DISEASE PATHOGENESIS; AMYOTROPHIC-LATERAL-SCLEROSIS; SELECTIVE CHOLINERGIC LESION;

D O I：

10.3233/JAD-140228

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Scientists working in the fields of Alzheimer's disease and, in particular, cognitive enhancers are very productive. The review "Cognitive enhancers (nootropics): drugs interacting with receptors" was accepted for publication in July 2012. Since then, new targets for the potential treatment of Alzheimer's disease were identified. This update describes drugs interacting with 42 receptors versus 32 receptors in the first paper. Some compounds progressed in their development, while many others were discontinued. The present review covers the evolution of research in this field through March 2014.

引用

页码：961 / 1019

页数：59

共 576 条

[1]

Abbas A, 2008, EXPERT OPIN PHARMACO, V9, P3251, DOI [10.1517/14656560802532707, 10.1517/14656560802532707 ]

[2] Genetic Ablation of Tau Mitigates Cognitive Impairment Induced by Type 1 Diabetes [J].

Abbondante, Serena ;

Baglietto-Vargas, David ;

Rodriguez-Ortiz, Carlos J. ;

Estrada-Hernandez, Tatiana ;

Medeiros, Rodrigo ;

LaFerla, Frank M. .

AMERICAN JOURNAL OF PATHOLOGY, 2014, 184 (03) :819-826

[3] Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor [J].

Abdul-Ridha, Alaa ;

Lopez, Laura ;

Keov, Peter ;

Thal, David M. ;

Mistry, Shailesh N. ;

Sexton, Patrick M. ;

Lane, J. Robert ;

Canals, Meritxell ;

Christopoulos, Arthur .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (09) :6067-6079

[4] Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series [J].

Achermann, Guido ;

Ballard, Theresa M. ;

Blasco, Francesca ;

Broutin, Pierre-Emmanuel ;

Buettelmann, Bernd ;

Fischer, Holger ;

Graf, Martin ;

Hernandez, Maria-Clemencia ;

Hilty, Peter ;

Knoflach, Frederic ;

Koblet, Andreas ;

Knust, Henner ;

Kurt, Anke ;

Martin, James R. ;

Masciadri, Raffaello ;

Porter, Richard H. P. ;

Stadler, Heinz ;

Thomas, Andrew W. ;

Trube, Gerhard ;

Wichmann, Juergen .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (19) :5746-5752

[5]

Adeghate E, 2013, CURR ALZHEIMER RES, V10, P609

[6] Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition [J].

Adler, Brittany L. ;

Yarchoan, Mark ;

Hwang, Hae Min ;

Louneva, Natalia ;

Blair, Jeffrey A. ;

Palm, Russell ;

Smith, Mark A. ;

Lee, Hyoung-gon ;

Arnold, Steven E. ;

Casadesus, Gemma .

NEUROBIOLOGY OF AGING, 2014, 35 (04) :793-801

[7] The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide [J].

Ago, Yukio ;

Hiramatsu, Naoki ;

Ishihama, Toshihiro ;

Hazama, Keisuke ;

Hayata-Takano, Atsuko ;

Shibasaki, Yasuhiro ;

Shintani, Norihito ;

Hashimoto, Hitoshi ;

Kawasaki, Toshiyuki ;

Onoe, Hirotaka ;

Chaki, Shigeyuki ;

Nakazato, Atsuro ;

Baba, Akemichi ;

Takuma, Kazuhiro ;

Matsuda, Toshio .

BEHAVIOURAL PHARMACOLOGY, 2013, 24 (01) :74-77

[8] Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice [J].

Ago, Yukio ;

Yano, Koji ;

Araki, Ryota ;

Hiramatsu, Naoki ;

Kita, Yuki ;

Kawasaki, Toshiyuki ;

Onoe, Hirotaka ;

Chaki, Shigeyuki ;

Nakazato, Atsuro ;

Hashimoto, Hitoshi ;

Baba, Akemichi ;

Takuma, Kazuhiro ;

Matsuda, Toshio .

NEUROPHARMACOLOGY, 2013, 65 :29-38

[9] Overlapped Metabolic and Therapeutic Links between Alzheimer and Diabetes [J].

Ahmad, Waqar .

MOLECULAR NEUROBIOLOGY, 2013, 47 (01) :399-424

[10] Loss of P2Y2 Nucleotide Receptors Enhances Early Pathology in the TgCRND8 Mouse Model of Alzheimer's Disease [J].

Ajit, Deepa ;

Woods, Lucas T. ;

Camden, Jean M. ;

Thebeau, Christina N. ;

El-Sayed, Farid G. ;

Greeson, Glen W. ;

Erb, Laurie ;

Petris, Michael J. ;

Miller, Douglas C. ;

Sun, Grace Y. ;

Weisman, Gary A. .

MOLECULAR NEUROBIOLOGY, 2014, 49 (02) :1031-1042

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