Antibacterial endiandric acid, derivatives from Beilschmiedia anacardioides

被引：33

作者：

Chouna, Jean Rodolphe ^{[1
]}

Nkeng-Efouet, Pepin Alango ^{[4
]}

Lenta, Bruno Ndjakou ^{[2
,3
]}

Devkota, Krishna Prasad ^{[3
]}

Neumann, Beate ^{[3
]}

Stammler, Hans-Georg ^{[3
]}

Kimbu, Samuel Fon ^{[1
]}

Sewald, Norbert ^{[3
]}

机构：

[1] Univ Yaounde 1, Dept Organ Chem, Yaounde, Cameroon

[2] Univ Yaounde 1, Higher Teachers Training Coll, Dept Chem, Yaounde, Cameroon

[3] Univ Bielefeld, Dept Chem, D-33501 Bielefeld, Germany

[4] Univ Dschang, Dept Chem, Dschang, Cameroon

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 05期

关键词：

Beilschmeidia anacardioides; Lauraceae; Beilschmiedic acids A; B and C; X-ray analysis; Antibacterial; CONSTITUENTS; LAURACEAE; TSANGII; LIGNANS;

D O I：

10.1016/j.phytochem.2009.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures were established by means of modern spectroscopic techniques. The relative configuration of compound 1 was determined by single crystal X-ray analysis. The antibacterial activities of compounds A,B,C were evaluated in vitro against five strains of microbes. Compound C showed strong activity against Bacillus subtilis, Micrococcus luteus and Streptococcus faecalis (MICs below 23 mu M). This Compound was more active than the reference antibiotic ampicillin against B. subtilis and M. luteus. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：684 / 688

页数：5

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