Artificial DNA Base Pairing Mediated by Diverse Metal Ions

被引：132
作者：
Takezawa, Yusuke [1 ]
Mueller, Jens [2 ]
Shionoya, Mitsuhiko [1 ]
机构：
[1] Univ Tokyo, Grad Sch Sci, Dept Chem, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
[2] Westfalische Wilhelms Univ Munster, Inst Anorgan & Analyt Chem, Corrensstr 28-30, D-48149 Munster, Germany
来源：
CHEMISTRY LETTERS | 2017年 / 46卷 / 05期
关键词：
Artificial DNA; Metal-mediated base pairing; DNA-based supermolecule; TEMPLATE-INDEPENDENT POLYMERASE; DOUBLE-STRANDED POLYNUCLEOTIDES; PEPTIDE NUCLEIC-ACIDS; MODIFIED PNA DUPLEXES; HG-II-T; ENZYMATIC-SYNTHESIS; REVERSIBLE-REACTION; 3-WAY JUNCTIONS; CROSS-LINKING; DOUBLE HELIX;
D O I：
10.1246/cl.160985
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Metal-mediated artificial DNA base pairs, consisting of two ligand-type nucleosides and a bridging metal ion, are promising building units for constructing DNA-based supermolecules. Metallo-base pairing allows the thermal stabilization and site-specific functionalization of DNA duplexes. In this review, representative examples of the metallo-base pairs are classified according to the metal species, and their structures and properties are highlighted. Recent applications including polymerase synthesis are also overviewed to illustrate the future directions of this research field.
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页码：622 / 633
页数：12
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