Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue

被引：9
|
作者：
Smutzer, G [1 ]
Zimmerman, JE [1 ]
Hahn, CG [1 ]
Ruscheinsky, DD [1 ]
Rodriguez, A [1 ]
Han, LY [1 ]
Arnold, SE [1 ]
机构：
[1] UNIV PENN, SCH MED, DEPT NEUROL, PHILADELPHIA, PA 19104 USA
来源：
MOLECULAR BRAIN RESEARCH | 1997年 / 44卷 / 02期
关键词：
IP3; receptor; gene expression; olfaction; alternate splicing; signal transduction; sensory epithelium; secretion; calcium channel;
D O I：
10.1016/S0169-328X(96)00282-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Two cDNAs encoding inositol 1,4,5-trisphosphate (IP3) receptors were amplified from rat olfactory tissue, and both exhibited 100% sequence identity to the short (Segment II-) variant of type IP3 receptor. Type III IP3 receptor was also expressed in olfactory tissue. The distribution of IP3 receptors included the olfactory epithelium, lamina propria, and glandular tissue. These results demonstrate the co-expression of multiple IP3 receptor subtypes in olfactory cells, and suggest multiple functions for IP3 receptors in this tissue.
引用
收藏
页码：347 / 354
页数：8
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