Preserved visual-vestibular interaction in patients with bilateral vestibular failure

被引:26
作者
Bense, S
Deutschländer, A
Stephan, T
Bartenstein, P
Schwaiger, M
Brandt, T
Dieterich, M
机构
[1] Johannes Gutenberg Univ Mainz, Dept Neurol, D-55101 Mainz, Germany
[2] Johannes Gutenberg Univ Mainz, Dept Nucl Med, D-55101 Mainz, Germany
[3] Univ Munich, Dept Neurol, D-8000 Munich, Germany
[4] Tech Univ Munich, Dept Nucl Med, D-8000 Munich, Germany
关键词
D O I
10.1212/01.WNL.0000129545.79566.6A
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: During caloric vestibular stimulation, subjects showed bilateral activation of the vestibular cortex in the posterior insula and retroinsular region as well as concurrent deactivation of visual cortex areas bilaterally. This finding was the basis for the concept of a reciprocal inhibitory interaction between the vestibular and the visual systems. Objective: To analyze the modulations of this activation and deactivation pattern in patients with loss of vestibular input, that is, in patients with bilateral vestibular failure ( BVF). Methods: Modulations of regional cerebral blood flow (rCBF) in PET were measured in nine patients with BVF and compared with those in healthy volunteers using statistical group as well as single-subject analyses (Statistical Parametric Mapping 96b). Results: The group analysis of the BVF patients showed only one small region of activation in the posterior insula contralateral to the stimulated ear, whereas the other areas correlating with vestibular, autonomic, and ocular motor function were not activated. Furthermore, the concurrent rCBF decreases of the primary visual cortex seen in healthy volunteers were not found in the patients. These decreases seem to be dependent on an intact vestibular input with concurrent vestibular nystagmus. Conclusions: The results are compatible with the concept of a reciprocal inhibitory sensorisensory interaction between the vestibular and visual systems that normally act together for orientation in space and perception of motion. This interaction appears to be preserved in the patients at a significantly lower level, that is, with less activation and less deactivation.
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页码:122 / 128
页数:7
相关论文
共 35 条
[1]  
BALOH RW, 1989, WESTERN J MED, V150, P59
[2]   Multisensory cortical signal increases and decreases during vestibular galvanic stimulation (fMRI) [J].
Bense, S ;
Stephan, T ;
Yousry, TA ;
Brandt, T ;
Dieterich, M .
JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (02) :886-899
[3]   Reciprocal inhibitory visual-vestibular interaction - Visual motion stimulation deactivates the parieto-insular vestibular cortex [J].
Brandt, T ;
Bartenstein, P ;
Janek, A ;
Dieterich, M .
BRAIN, 1998, 121 :1749-1758
[4]  
Buchanan JJ, 2001, J VESTIBUL RES-EQUIL, V11, P371
[5]  
Buchele W, 1988, Adv Otorhinolaryngol, V42, P157
[6]   Sensorimotor cerebral activation during optokinetic nystagmus - A functional MRI study [J].
Bucher, SF ;
Dieterich, M ;
Seelos, KC ;
Brandt, T .
NEUROLOGY, 1997, 49 (05) :1370-1377
[7]   3-DIMENSIONAL ASPECTS OF CALORIC NYSTAGMUS IN HUMANS .1. THE INFLUENCE OF INCREASED GRAVITOINERTIAL FORCE [J].
CLARKE, AH ;
TEIWES, W ;
OELHAFEN, P ;
SCHERER, H .
ACTA OTO-LARYNGOLOGICA, 1993, 113 (06) :687-692
[8]   Dominance for vestibular cortical function in the non-dominant hemisphere [J].
Dieterich, M ;
Bense, S ;
Lutz, S ;
Drzezga, A ;
Stephan, T ;
Bartenstein, P ;
Brandt, T .
CEREBRAL CORTEX, 2003, 13 (09) :994-1007
[9]   fMRI signal increases and decreases in cortical areas during small-field optokinetic stimulation and central fixation [J].
Dieterich, M ;
Bense, S ;
Stephan, T ;
Yousry, TA ;
Brandt, T .
EXPERIMENTAL BRAIN RESEARCH, 2003, 148 (01) :117-127
[10]   Brain activation studies on visual-vestibular and ocular motor interaction [J].
Dieterich, M ;
Brandt, T .
CURRENT OPINION IN NEUROLOGY, 2000, 13 (01) :13-18