Interleukin 31 is involved in intrahepatic cholestasis of pregnancy

被引：14

作者：

Basile, F. ^{[1
]}

Santamaria, A. ^{[1
]}

Mannucci, C. ^{[2
]}

Rizzo, L. ^{[1
]}

Gangemi, S. ^{[2
]}

D'anna, R. ^{[1
]}

Arcoraci, V. ^{[2
]}

机构：

[1] Univ Messina, Dept Human Pathol & Dev, Messina, Italy

[2] Univ Messina, Dept Clin & Expt Med, Messina, Italy

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2017年 / 30卷 / 09期

关键词：

Cytokines; intrahepatic cholestasis of pregnancy; interleukin; 31; liver transaminases; T-CELLS; INFLAMMATION; IL-31;

D O I：

10.1080/14767058.2016.1205025

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder characterized by maternal itching and altered liver function. Interleukin (IL)-31 is known to be involved in the pathogenesis of pruritic inflammatory skin diseases. In a three-year period, 13 women with a singleton pregnancy and a diagnosis of intrahepatic cholestasis (ICP) were enrolled together with 26 healthy single pregnant women who concluded an uncomplicated pregnancy. The inclusion criteria were itching and elevated levels of liver transaminases. Median serum levels of IL-31 were significantly higher in ICP patients than in the control group (p=0.004). Furthermore, IL-31 values were directly dependent on liver transaminase levels.

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收藏

页码：1124 / 1127

页数：4

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