Traceable in-cell synthesis and cytoplasm-to-nucleus translocation of a zinc Schiff base complex as a simple and economical anticancer strategy

被引：23

作者：

Cao, Qian ^{[1
]}

Yang, Jing ^{[1
]}

Zhang, Hang ^{[1
]}

Hao, Liang ^{[1
]}

Yang, Gang-Gang ^{[1
]}

Ji, Liang-Nian ^{[1
]}

Mao, Zong-Wan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 54期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

D O I：

10.1039/c9cc03480c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have proposed a facile and cheap cancer therapeutic strategy by in-cell synthesizing theranostic Zn Schiff base complexes with nuclear targeting and DNA damaging capability. The in-cell synthesis can be traced via a green-to-blue fluorescence shift, and the subsequent cytoplasm-to-nucleus translocation realizes cancer-specific therapy both in vitro and in vivo.

引用

页码：7852 / 7855

页数：4

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