Fecal Biomarkers in the Diagnosis and Monitoring of Crohn's Disease

被引：35

作者：

Wright, Emily K. ^{[1
,2
]}

De Cruz, Peter ^{[1
,2
]}

Gearry, Richard ^{[3
,4
]}

Day, Andrew S. ^{[3
,4
]}

Kamm, Michael A. ^{[1
,2
]}

机构：

[1] St Vincents Hosp, Melbourne, Vic 3065, Australia

[2] Univ Melbourne, Melbourne, Vic, Australia

[3] Christchurch Hosp, Christchurch, New Zealand

[4] Univ Otago, Christchurch, New Zealand

来源：

INFLAMMATORY BOWEL DISEASES | 2014年 / 20卷 / 09期

关键词：

Crohn's disease; inflammatory bowel disease; stool tests; fecal biomarkers; calprotectin; lactoferrin; S100A12; postoperative; INFLAMMATORY-BOWEL-DISEASE; C-REACTIVE PROTEIN; INTESTINAL INFLAMMATION; CALPROTECTIN LEVELS; ULCERATIVE-COLITIS; NONINVASIVE MARKER; SURROGATE MARKERS; COLORECTAL-CANCER; ACTIVITY INDEX; GASTROINTESTINAL SYMPTOMS;

D O I：

10.1097/MIB.0000000000000087

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The diagnosis and monitoring of Crohn's disease has traditionally relied on clinical assessment, serum markers of inflammation, and endoscopic examination. Fecal biomarkers such as calprotectin, lactoferrin, and S100A12 are predominantly derived from neutrophils, are easily detectable in the feces, and are emerging as valuable markers of intestinal inflammation. This review focuses on the role of fecal biomarkers in the diagnosis and monitoring of Crohn's disease, in particular how these biomarkers change with disease activity and remission, how they can be used to monitor the response to medical therapy, their value in predicting clinical relapse, and their role in monitoring the postoperative state.

引用

页码：1668 / 1677

页数：10

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