Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome

被引：10

作者：

Ahn, Yeongseon ^{[1
]}

Lee, Hyejin ^{[2
]}

Cho, Yoon Shin ^{[1
]}

机构：

[1] Hallym Univ, Dept Biomed Sci, Chunchon 24252, Gangwon Do, South Korea

[2] Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea

来源：

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2020年 / 13卷

基金：

新加坡国家研究基金会;

关键词：

female obesity; polycystic ovarian syndrome; causal relation; genome-wide association study; Mendelian randomization; GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; MENDELIAN RANDOMIZATION; GENOTYPE IMPUTATION; LOCI; METAANALYSIS; EFFICIENT;

D O I：

10.2147/DMSO.S281529

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Observational studies have demonstrated an increased risk of polycystic ovarian syndrome (PCOS) in obese women. This study aimed to identify genetic variants influencing obesity in females and to evaluate the causal association between genetically defined obesity and PCOS in Korean women. Methods: Two-stage GWAS was conducted to identify genetic variants influencing obesity traits (such as body mass index [BMI], waist-hip ratio [WHR], and waist circumference [WC]) in Korean women. Two-sample Mendelian randomization (MR) analysis was employed to evaluate the causal effect of variants as genetic instruments for female obesity on PCOS. Results: Meta-analysis of 9953 females combining discovery (N = 4658) and replication (N = 5295) stages detected four (rs11162584, rs6760543, rs828104, rs56137030), six (rs139702234, rs2341967, rs73059848, rs5020945, rs550532151, rs61971548), and two genetic variants (rs7722169, rs7206790) suggesting a highly significant association (P < 1x10-6) with BMI, WHR, and WC, respectively. Of these, an intron variant rs56137030 in FTO achieved genome-wide significant association (P = 3.39x10-8) with BMI in females. Using variants for female obesity, their effect on PCOS in 946 cases and 976 controls was evaluated by MR analysis. MR results indicated no significant association between genetically defined obesity and PCOS in Korean women. Conclusion: This study, for the first time, revealed genetic variants for female obesity in the Korean population and reported no causal association between genetically defined obesity and PCOS in Korean women.

引用

页码：4311 / 4322

页数：12

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