Islet cell transplantation

被引：18

作者：

McCall, Michael ^{[1
]}

Shapiro, A. M. James ^{[1
,2
]}

机构：

[1] Univ Alberta, Dept Surg, Edmonton, AB, Canada

[2] Univ Alberta, Clin Islet Transplant Program, Edmonton, AB, Canada

来源：

SEMINARS IN PEDIATRIC SURGERY | 2014年 / 23卷 / 02期

关键词：

Pancreas; Islets; Transplantation; Diabetes; Cells; QUALITY-OF-LIFE; TYPE-1; DIABETIC-PATIENTS; INSULIN INDEPENDENCE; PANCREATIC-ISLETS; SIROLIMUS WITHDRAWAL; PORTAL-HYPERTENSION; SINGLE-DONOR; LARGE-SCALE; COLLAGENASE; MELLITUS;

D O I：

10.1053/j.sempedsurg.2014.03.006

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Islet transplantation has become a promising treatment for selected patients with type 1 diabetes. Here we provide an overview of the procedure including its history, the process of donor selection, and the techniques and procedures involved in a successful transplant. A brief overview of the current immunosuppressive regimens, the long-term follow-up and the reported outcomes will also be discussed. While islet transplantation is currently generally reserved for adults with type 1 diabetes with severe hypoglycemia or glycemic lability, we herein consider the possibility of its application to the pediatric population. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：83 / 90

页数：8

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