The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells

被引：61

作者：

Chen, Chong ^{[1
]}

Liu, Yu ^{[1
]}

Liu, Yang ^{[1
,2
]}

Zheng, Pan ^{[1
,3
]}

机构：

[1] Univ Michigan, Dept Surg, Sch Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA

来源：

CELL CYCLE | 2009年 / 8卷 / 08期

关键词：

hematopoietic stem cells; mitochondria; mTOR; reactive oxygen species; quiescence; SELF-RENEWAL; SERIAL TRANSPLANTATION; PROLIFERATIVE CAPACITY; QUIESCENCE; VIVO; CYCLE; DIFFERENTIATION; PROGRESSION; GROWTH; MICE;

D O I：

10.4161/cc.8.8.8139

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has been hypothesized that adult hematopoietic stem cells (HSCs) need to remain quiescent to retain their long-term self-renewal activity and multipotency. However, it is still unclear how lack of quiescence is detrimental to HSC. We identified that the mTOR pathway is the key to HSCs quiescence. mTOR overactivation caused increased mitochondrial biogenesis and accumulation of much higher level of reactive oxygen species (ROS). Removal of ROS rescued HSC defects associated with hyperactivated mTOR. We propose susceptibility to ROS as the underlying cause for HSC's general requirement for quiescence.

引用

页码：1158 / 1160

页数：3

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