Performance evaluation of the fully engineered YAP-(S)PET scanner for small animal imaging

被引:60
作者
Del Guerra, A [1 ]
Bartoli, A
Belcari, N
Herbert, D
Motta, A
Vaiano, A
Di Domenico, G
Sabba, N
Moretti, E
Zavattini, G
Lazzarotti, M
Sensi, L
Larobina, M
Uccelli, L
机构
[1] Univ Pisa, Dept Phys, I-56127 Pisa, Italy
[2] Univ Pisa, Ctr Excellence AmbiSEN, I-56127 Pisa, Italy
[3] Ist Nazl Fis Nucl, I-56127 Pisa, Italy
[4] Univ Ferrara, Dept Phys, I-44100 Ferrara, Italy
[5] Ist Nazl Fis Nucl, I-44100 Ferrara, Italy
[6] ISE srl, I-56010 Vecchiano, PI, Italy
[7] CNR, Ist Biostrutture & Bioimmagini, I-80100 Naples, Italy
[8] Univ Ferrara, Lab Nucl Med & Mol Imaging, Dept Radiol Sci, I-44100 Ferrara, Italy
关键词
molecular imaging; positron emission tomography (PET); single photon emission tomography; small animal imaging;
D O I
10.1109/TNS.2006.871900
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
At the Department of Physics of the University of Pisa, Italy, a new and fully engineered version of the YAP-(S)PET small animal scanner has been recently installed. The new YAP-(S)PET is able to perform both PET and SPECT studies on small animals. The scanner is made up of four heads: each one is composed of a 4 x 4 cm(2) YAlO3:Ce (or YAP:Ce) matrix of 20 x 20 elements, 2 x 2 x 25 mm(3) each, coupled to a Position Sensitive Photomultiplier (PS-PMT) (Hamamatsu R2486). The four modules are positioned on a rotating gantry. The switching to the SPECT modality is easily made by mounting a high resolution parallel hole (0.6 mm circle divide, 0.15 mm septum) lead collimator in front of each crystal. This paper reports the performance of the system in terms of absolute sensitivity and spatial resolution for both PET and SPECT modalities. The scatter fraction and noise-equivalent count rate (NEC) for a mouse phantom for different energy windows have been measured in PET modality. Images of phantoms and animals are also presented.
引用
收藏
页码:1078 / 1083
页数:6
相关论文
共 9 条
[1]  
[Anonymous], 2001, NEMA STAND PUBL
[2]   An integrated PET-SPECT small animal imager: preliminary results [J].
Del Guerra, A ;
Damiani, C ;
Di Domenico, G ;
Motta, A ;
Giganti, M ;
Marchesini, R ;
Piffanelli, A ;
Sabba, N ;
Sartori, L ;
Zavattini, G .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2000, 47 (04) :1537-1540
[3]   High spatial resolution small animal YAP-PET [J].
Del Guerra, A ;
Di Domenico, G ;
Scandola, M ;
Zavattini, G .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 1998, 409 (1-3) :537-541
[4]  
DELGUERRA A, 2002, 2002 ANN C AC MOL IM
[5]  
DELGUERRA A, SMALL ANIMAL SPECT I, pCH17
[6]  
DIDOMENICO G, IEEE T NUCL SCI, V50, P1351
[7]   Use of a fast EM algorithm for 3D image reconstruction with the YAP-PET tomograph [J].
Motta, A ;
Damiani, C ;
Del Guerra, A ;
Di Domenico, G ;
Zavattini, G .
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, 2002, 26 (05) :293-302
[8]  
National Electrical Manufacturers Association, 1994, NEMA STAND PUBL
[9]   Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging [J].
Yang, YF ;
Tai, YC ;
Siegel, S ;
Newport, DF ;
Bai, B ;
Li, QZ ;
Leahy, RM ;
Cherry, SR .
PHYSICS IN MEDICINE AND BIOLOGY, 2004, 49 (12) :2527-2545