Synthesis of 3,4-diarylsubstituted hexahydro-1H-indoles

被引：2

作者：

Zhou, Feilong ^{[1
,2
]}

Zhao, Erbao ^{[1
,2
]}

Yan, Ziqin ^{[2
]}

Chen, Deheng ^{[2
,3
]}

Zhao, Yujun ^{[2
]}

机构：

[1] Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Aziridine; Hypersaturated indole; Cation; Allylic cation; Cyclization; MISCELLANEOUS ALKALOIDS; BUILDING-BLOCKS; SCELETIUM; CONSTRUCTION; AZIRIDINES; INHIBITORS; POTENT; OCTAHYDROINDOLES; AMARYLLIDACEAE; IMIDAZOLE;

D O I：

10.1016/j.tetlet.2018.04.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient syntheses of 3,4-diarylsubstituted hexahydro-1H-indoles in good yields with excellent diastere-oselectivities were achieved with a two-step protocol comprising an allylic cation mediated nucleophilic addition and an intramolecular cyclization reaction. The N-aryl sulfonyl protecting groups of cyclization products were readily removed to furnish free amines with retention of halogen substitutions and C-C double bonds. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：1871 / 1874

页数：4

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