Hyaluronan-binding receptors: possible involvement in osteoarthritis

被引：20

作者：

Dunn, Sharon ^{[2
]}

Kolomytkin, Oleg V. ^{[1
]}

Waddell, David D. ^{[1
]}

Marino, Andrew A. ^{[1
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Orthopaed Surg, Shreveport, LA 71130 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Sch Allied Hlth, Shreveport, LA 71130 USA

来源：

MODERN RHEUMATOLOGY | 2009年 / 19卷 / 02期

关键词：

CD44; Hyaluronan-binding proteins; Osteoarthritis; RHAMM; HUMAN SYNOVIAL TISSUE; RHEUMATOID-ARTHRITIS; CD44; ACID; EXPRESSION; PARAMETERS; MOLECULE; CELLS; FLUID;

D O I：

10.1007/s10165-008-0136-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients with advanced OA. Expression of CD44 and RHAMM were each significantly increased (p < 0.05) in synovial tissue from patients with OA, as determined by means of Western-blot analysis. The findings suggested that changes in levels of the HA-binding proteins might be implicated in the development or progression of OA.

引用

页码：151 / 155

页数：5

共 20 条

[11]

Lokeshwar VB, 2000, J BIOL CHEM, V275, P27641

[12] Subcellular distribution, calmodulin interaction, and mitochondrial association of the hyaluronan-binding protein RHAMM in rat brain [J].

Lynn, BD ;

Turley, EA ;

Nagy, JI .

JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 65 (01) :6-16

[13] CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain [J].

Mori, H ;

Tomari, T ;

Koshikawa, N ;

Kajita, M ;

Itoh, Y ;

Sato, H ;

Tojo, H ;

Yana, I ;

Seiki, M .

EMBO JOURNAL, 2002, 21 (15) :3949-3959

[14] CELL AGGREGATION - ROLE OF ACID MUCOPOLYSACCHARIDES [J].

PESSAC, B ;

DEFENDI, V .

SCIENCE, 1972, 175 (4024) :898-+

[15] CD44: From adhesion molecules to signalling regulators [J].

Ponta, H ;

Sherman, L ;

Herrlich, PA .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (01) :33-45

[16] Hyaluronan fragments: An information-rich system [J].

Stern, Robert ;

Asari, Akira A. ;

Sugahara, Kazuki N. .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2006, 85 (08) :699-715

[17] Hyaluronan: From extracellular glue to pericellular cue [J].

Toole, BP .

NATURE REVIEWS CANCER, 2004, 4 (07) :528-539

[18]

TURLEY EA, 2002, J BIOL CHEM, V277, P4575

[19] Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion [J].

Yu, Q ;

Stamenkovic, I .

GENES & DEVELOPMENT, 1999, 13 (01) :35-48

[20] CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling [J].

Yu, WH ;

Woessner, JF ;

McNeish, JD ;

Stamenkovic, I .

GENES & DEVELOPMENT, 2002, 16 (03) :307-323

← 1 2 →