Hyaluronan-binding receptors: possible involvement in osteoarthritis

被引：20

作者：

Dunn, Sharon ^{[2
]}

Kolomytkin, Oleg V. ^{[1
]}

Waddell, David D. ^{[1
]}

Marino, Andrew A. ^{[1
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Orthopaed Surg, Shreveport, LA 71130 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Sch Allied Hlth, Shreveport, LA 71130 USA

来源：

MODERN RHEUMATOLOGY | 2009年 / 19卷 / 02期

关键词：

CD44; Hyaluronan-binding proteins; Osteoarthritis; RHAMM; HUMAN SYNOVIAL TISSUE; RHEUMATOID-ARTHRITIS; CD44; ACID; EXPRESSION; PARAMETERS; MOLECULE; CELLS; FLUID;

D O I：

10.1007/s10165-008-0136-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients with advanced OA. Expression of CD44 and RHAMM were each significantly increased (p < 0.05) in synovial tissue from patients with OA, as determined by means of Western-blot analysis. The findings suggested that changes in levels of the HA-binding proteins might be implicated in the development or progression of OA.

引用

页码：151 / 155

页数：5

共 20 条

[1]

Assmann V, 1999, J CELL SCI, V112, P3943

[2] Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity [J].

Baeten, D ;

Demetter, P ;

Cuvelier, C ;

Van den Bosch, F ;

Kruithof, E ;

Van Damme, N ;

Verbruggen, G ;

Mielants, H ;

Veys, EM ;

De Keyser, F .

ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 (12) :945-953

[3] HYALURONIC ACID IN SYNOVIAL FLUID .I. MOLECULAR PARAMETERS OF HYALURONIC ACID IN NORMAL AND ARTHRITIC HUMAN FLUIDS [J].

BALAZS, EA ;

WATSON, D ;

DUFF, IF ;

ROSEMAN, S .

ARTHRITIS AND RHEUMATISM, 1967, 10 (04) :357-&

[4]

Cantor Jerome O., 2006, Inflammation & Allergy Drug Targets, V5, P257, DOI 10.2174/187152806779010936

[5] THE MICROSCOPIC STRUCTURE OF NORMAL HUMAN SYNOVIAL TISSUE [J].

CASTOR, CW .

ARTHRITIS AND RHEUMATISM, 1960, 3 (02) :140-151

[6] CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma [J].

Clark, RA ;

Alon, R ;

Springer, TA .

JOURNAL OF CELL BIOLOGY, 1996, 134 (04) :1075-1087

[7] CONCENTRATION AND MOLECULAR-WEIGHT OF SODIUM HYALURONATE IN SYNOVIAL-FLUID FROM PATIENTS WITH RHEUMATOID-ARTHRITIS AND OTHER ARTHROPATHIES [J].

DAHL, LB ;

DAHL, IMS ;

ENGSTROMLAURENT, A ;

GRANATH, K .

ANNALS OF THE RHEUMATIC DISEASES, 1985, 44 (12) :817-822

[8] Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:: Polycytidylic acid -: Inter-α-trypsin inhibitor is crucial to structure and function [J].

de la Motte, CA ;

Hascall, VC ;

Drazba, J ;

Bandyopadhyay, SK ;

Strong, SA .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (01) :121-133

[9] Expression of the CD44 variant isoform 5 in the human osteoarthritic knee joint: correlation with radiological, histomorphological, and biochemical parameters [J].

Fuchs, S ;

Dankbar, B ;

Wildenau, G ;

Goetz, W ;

Lohmann, CH ;

Tibesku, CO .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2004, 22 (04) :774-780

[10] ADHESION MOLECULE EXPRESSION IN HUMAN SYNOVIAL TISSUE [J].

JOHNSON, BA ;

HAINES, GK ;

HARLOW, LA ;

KOCH, AE .

ARTHRITIS AND RHEUMATISM, 1993, 36 (02) :137-146

← 1 2 →