Time cells in the hippocampus: a new dimension for mapping memories

被引：438
作者：
Eichenbaum, Howard [1 ]
机构：
[1] Boston Univ, Ctr Memory & Brain, Boston, MA 02215 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 11期
关键词：
MEDIAL TEMPORAL-LOBE; EPISODIC MEMORY; ASSEMBLY SEQUENCES; DEFERRED IMITATION; ENTORHINAL CORTEX; NEURAL MECHANISMS; SINGLE NEURONS; PLACE; ORDER; REPRESENTATION;
D O I：
10.1038/nrn3827
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent studies have revealed the existence of hippocampal neurons that fire at successive moments in temporally structured experiences. Several studies have shown that such temporal coding is not attributable to external events, specific behaviours or spatial dimensions of an experience. Instead, these cells represent the flow of time in specific memories and have therefore been dubbed 'time cells'. The firing properties of time cells parallel those of hippocampal place cells; time cells thus provide an additional dimension that is integrated with spatial mapping. The robust representation of both time and space in the hippocampus suggests a fundamental mechanism for organizing the elements of experience into coherent memories.
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收藏
页码：732 / 744
页数：13
相关论文
共 106 条
[1]   Deferred imitation of action sequences in developmental amnesia [J].
Adlam, ALR ;
Vargha-Khadem, F ;
Mishkin, M ;
de Haan, M .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2005, 17 (02) :240-248
[2]  
Agster KL, 2002, J NEUROSCI, V22, P5760
[3]   Hippocampal CA1 place cells encode intended destination on a maze with multiple choice points [J].
Ainge, James A. ;
Tamosiunaite, Minija ;
Woergoetter, Florentin ;
Dudchenko, Paul A. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (36) :9769-9779
[4]   The parahippocampal cortex mediates spatial and nonspatial associations [J].
Aminoff, E. ;
Gronau, N. ;
Bar, M. .
CEREBRAL CORTEX, 2007, 17 (07) :1493-1503
[5]  
[Anonymous], 1983, Canadian Psychology
[6]   SINGLE-UNIT ANALYSIS OF DIFFERENT HIPPOCAMPAL CELL-TYPES DURING CLASSICAL-CONDITIONING OF RABBIT NICTITATING-MEMBRANE RESPONSE [J].
BERGER, TW ;
RINALDI, PC ;
WEISZ, DJ ;
THOMPSON, RF .
JOURNAL OF NEUROPHYSIOLOGY, 1983, 50 (05) :1197-1219
[7]   Which Way Was I Going? Contextual Retrieval Supports the Disambiguation of Well Learned Overlapping Navigational Routes [J].
Brown, Thackery I. ;
Ross, Robert S. ;
Keller, Joseph B. ;
Hasselmo, Michael E. ;
Stern, Chantal E. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (21) :7414-7422
[8]   What makes us tick? Functional and neural mechanisms of interval timing [J].
Buhusi, CV ;
Meck, WH .
NATURE REVIEWS NEUROSCIENCE, 2005, 6 (10) :755-765
[9]  
Buzsaki G, 2013, Nature, V497, P568
[10]   Memory, navigation and theta rhythm in the hippocampal-entorhinal system [J].
Buzsaki, Gyoergy ;
Moser, Edvard I. .
NATURE NEUROSCIENCE, 2013, 16 (02) :130-138
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