Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: An international collaborative study

被引：57

作者：

Amit, Moran ^{[1
,2
,3
]}

Na'ara, Shorook ^{[1
,2
,3
]}

Trejo-Leider, Leonor ^{[4
]}

Ramer, Naomi ^{[5
]}

Burstein, David ^{[5
]}

Yue, Ma ^{[6
]}

Miles, Brett ^{[6
]}

Yang, Xinjie ^{[7
]}

Lei, Delin ^{[7
]}

Bjoerndal, Kristine ^{[8
,9
]}

Godballe, Christian ^{[8
,9
]}

Muecke, Thomas ^{[10
]}

Wolff, Klaus-Dietrich ^{[10
]}

Eckardt, Andre M. ^{[11
]}

Copelli, Chiara ^{[12
]}

Sesenna, Enrico ^{[12
]}

Patel, Snehal ^{[13
]}

Ganly, Ian ^{[13
]}

Gil, Ziv ^{[1
,2
,3
]}

机构：

[1] Rambam Med Ctr, Dept Otolaryngol Head & Neck Surg, Head & Neck Ctr, Haifa, Israel

[2] Technion Israel Inst Technol, Clin Res Inst Rambam, Rambam Med Ctr, Rappaport Fac Med, Haifa, Israel

[3] Technion Israel Inst Technol, Res Inst, Haifa, Israel

[4] Tel Aviv Med Ctr & Sch Med, Dept Pathol, Tel Aviv, Israel

[5] Mt Sinai Sch Med, Dept Pathol, New York, NY USA

[6] Mt Sinai Sch Med, Dept Otolaryngol, New York, NY USA

[7] Fourth Mil Med Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Xian, Peoples R China

[8] Odense Univ Hosp Denmark, Dept Otolaryngol Head & Neck Surg, Odense, Denmark

[9] Odense Univ Hosp Denmark, Dept Otolaryngol Head & Neck Surg, Bonn, Germany

[10] Tech Univ Munich, Dept Oral & Maxillofacial Surg, Munich, Germany

[11] Hannover Med Sch, Dept Craniomaxillofacial Surg, Hannover, Germany

[12] Univ Hosp Parma, Dept Maxillofacial Surg, Parma, Italy

[13] Mem Sloan Kettering Canc Ctr, Head & Neck Surg Serv, 1275 York Ave, New York, NY 10021 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 05期

关键词：

adenoid cystic carcinoma; survival; margins; paranasal sinuses; oral cavity; salivary gland; head and neck cancer; SQUAMOUS-CELL CARCINOMA; ORAL-CAVITY; POSITIVE MARGINS; PROGNOSTIC-FACTORS; HEAD; NECK; SURGERY; INVASION; CANCER; CLASSIFICATION;

D O I：

10.1002/hed.24740

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundThe mainstay of treatment in adenoid cystic carcinoma (ACC) of the head and neck is surgical resection with negative margins. The purpose of this study was to define the margin status that associates with survival outcomes of ACC of the head and neck. MethodsWe conducted univariate and multivariate analyses of international data. ResultsData of 507 patients with ACC of the head and neck were analyzed; negative margins defined as 5 mm were detected in 253 patients (50%). On multivariate analysis, the hazard ratios (HRs) of positive margin status were 2.68 (95% confidence interval [CI], 1.2-6.2; p = .04) and 2.63 (95% CI, 1.1-6.3; p = .03) for overall survival (OS) and disease-specific survival (DSS), respectively. Close margins had no significant impact on outcome, with HRs of 1.1 (95% CI, 0.4-3.0; p = .12) and 1.07 (95% CI, 0.3-3.4; p = .23) for OS and DSS, respectively, relative with negative margins. ConclusionIn head and neck ACC, positive margins are associated with the worst outcome. Negative or close margins are associated with improved outcome, regardless of the distance from the tumor. (c) 2017 Wiley Periodicals, Inc. Head Neck 39: 1008-1014, 2017

引用

页码：1008 / 1014

页数：7

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