A Synthetic Vaccine Consisting of a Tumor-Associated Sialyl-TN-MUC1 Tandem-Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly Selective Immune Response

被引：114

作者：

Kaiser, Anton ^{[1
]}

Gaidzik, Nikola ^{[1
]}

Westerlind, Ulrika ^{[1
]}

Kowalczyk, Danuta ^{[1
]}

Hobel, Alexandra ^{[2
]}

Schmitt, Edgar ^{[2
]}

Kunz, Horst ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Immunol, D-55101 Mainz, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 41期

关键词：

glycopeptides; protein conjugates; synthetic vaccines; tetanus toxoid; tumor-associated antigens; T-CELL EPITOPE; OVARIAN-CANCER PATIENTS; EPITHELIAL MUCIN MUC4; CONJUGATE VACCINE; BREAST-CANCER; CARBOHYDRATE ANTIGENS; O-GLYCOSYLATION; SIALOSYL-TN; PEPTIDES; IMMUNIZATION;

D O I：

10.1002/anie.200902564

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An ideal combination: The vaccine A is obtained by conjugation of the synthetic tumor-associated sialyl-TN- MUC1 glycopeptide antigen to tetanus toxoid (molecular weight >150 000). Vaccine A induces a very strong and selective immune response against the glycopeptide structure in wild-type mice (Balb/c). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7551 / 7555

页数：5

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