Calcium Homeostasis in Ventricular Myocytes of Diabetic Cardiomyopathy

被引:25
作者
Al Kury, Lina T. [1 ]
机构
[1] Zayed Univ, Coll Nat & Hlth Sci, Dept Hlth Sci, Abu Dhabi 144534, U Arab Emirates
关键词
CARDIAC RYANODINE RECEPTOR; SARCOPLASMIC-RETICULUM CA2+-ATPASE; GLYCATION END-PRODUCTS; RELEASE CHANNEL RYR2; GENE-EXPRESSION; CA2+ RELEASE; NA+/CA2+ EXCHANGER; NA+-CA2+ EXCHANGER; OXIDATIVE STRESS; NA/CA EXCHANGE;
D O I
10.1155/2020/1942086
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Diabetes mellitus (DM) is a chronic metabolic disorder commonly characterized by high blood glucose levels, resulting from defects in insulin production or insulin resistance, or both. DM is a leading cause of mortality and morbidity worldwide, with diabetic cardiomyopathy as one of its main complications. It is well established that cardiovascular complications are common in both types of diabetes. Electrical and mechanical problems, resulting in cardiac contractile dysfunction, are considered as the major complications present in diabetic hearts. Inevitably, disturbances in the mechanism(s) of Ca2+ signaling in diabetes have implications for cardiac myocyte contraction. Over the last decade, significant progress has been made in outlining the mechanisms responsible for the diminished cardiac contractile function in diabetes using different animal models of type I diabetes mellitus (TIDM) and type II diabetes mellitus (TIIDM). The aim of this review is to evaluate our current understanding of the disturbances of Ca2+ transport and the role of main cardiac proteins involved in Ca2+ homeostasis in the diabetic rat ventricular cardiomyocytes. Exploring the molecular mechanism(s) of altered Ca2+ signaling in diabetes will provide an insight for the identification of novel therapeutic approaches to improve the heart function in diabetic patients.
引用
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页数:12
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