Amiodarone-induced alveolar hemorrhage

被引:30
作者
Iskandar, Said B.
Abi-Saleh, Bernard
Keith, Rob L.
Byrd, Ryland P., Jr.
Roy, Thomas M.
机构
[1] Vet Affairs Med Ctr, Div Pulm & Crit Care Med, Mountain Home, TN 37684 USA
[2] E Tennessee State Univ, James H Quillen Coll Med, Div Pulm Dis & Crit Care Med, Johnson City, TN 37614 USA
关键词
amiodarone; pulmonary toxicity; alveolar hemorrhage;
D O I
10.1097/01.smj.0000208971.43461.bb
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Armodarone is increasingly prescribed for patients with ventricular and supraventricular tachyarrhythmias. Many adverse effects have been reported due to this drug and include injury to the liver, thyroid, cornea, skin, and neuromuscular system. Pulmonary toxicity is one of the more serious side effects of this anti-arrhythmic drug and is potentially fatal. Since the first case of amiodarone-induced pneumonitis was described in the early 1980s, amiodarone pneumonitis has been recognized as a distinctive and not uncommon form of drug-induced lung injury. On the other hand, amiodarone-induced pulmonary toxicity resulting in alveolar hemorrhage is rare. The authors report a patient with amiodarone-induced alveolar hemorrhage and review the literature.
引用
收藏
页码:383 / 387
页数:5
相关论文
共 25 条
[1]   AMIODARONE PULMONARY TOXICITY PRESENTING AS A SOLITARY LUNG MASS [J].
ARNON, R ;
RAZ, I ;
CHAJEKSHAUL, T ;
BERKMAN, N ;
FIELDS, S ;
BARON, H .
CHEST, 1988, 93 (02) :425-427
[2]   Acute pulmonary injury in association with amiodarone [J].
Brinker, A ;
Johnston, M .
CHEST, 2004, 125 (04) :1591-1592
[3]   Amiodarone pulmonary toxicity [J].
Camus, P ;
Martin, WJ ;
Rosenow, EC .
CLINICS IN CHEST MEDICINE, 2004, 25 (01) :65-+
[4]  
Connolly SJ, 1997, LANCET, V350, P1417
[5]   Evidence-based analysis of amiodarone efficacy and safety [J].
Connolly, SJ .
CIRCULATION, 1999, 100 (19) :2025-2034
[6]   Bronchoalveolar lavage in drug-induced lung disease [J].
Costabel, U ;
Uzaslan, E ;
Guzman, J .
CLINICS IN CHEST MEDICINE, 2004, 25 (01) :25-+
[7]   AMIODARONE-ASSOCIATED PULMONARY TOXICITY - A CLINICAL AND PATHOLOGICAL-STUDY OF 11 CASES [J].
DEAN, PJ ;
GROSHART, KD ;
PORTERFIELD, JG ;
IANSMITH, DH ;
GOLDEN, EB .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1987, 87 (01) :7-13
[8]   AMIODARONE PULMONARY TOXICITY - A MULTIDISCIPLINARY REVIEW OF CURRENT STATUS [J].
FRAIRE, AE ;
GUNTUPALLI, KK ;
GREENBERG, SD ;
CARTWRIGHT, J ;
CHASEN, MH .
SOUTHERN MEDICAL JOURNAL, 1993, 86 (01) :67-77
[9]   Very early onset of acute amiodarone pulmonary toxicity presenting with hemoptysis [J].
Goldstein, I ;
Topilsky, M ;
Segev, D ;
Isakov, A ;
Heller, I .
CHEST, 1997, 111 (05) :1446-1447
[10]   DIAGNOSTIC-VALUE OF HEMOSIDERIN-CONTAINING MACROPHAGES IN BRONCHOALVEOLAR LAVAGE [J].
GREBSKI, E ;
HESS, T ;
HOLD, G ;
SPEICH, R ;
RUSSI, E .
CHEST, 1992, 102 (06) :1794-1799