Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer

被引：43

作者：

Link, Theresa ^{[1
,2
,3
,4
,5
,6
,7
]}

Kuhlmann, Jan Dominik ^{[1
,2
,3
,4
,5
,6
,7
]}

Kobelt, Dennis ^{[3
,8
,9
,10
]}

Herrmann, Pia ^{[8
,9
]}

Vassileva, Yana D. ^{[1
,2
,3
,4
,5
,6
,7
]}

Kramer, Michael ^{[11
,12
]}

Frank, Kerstin ^{[13
]}

Goeckenjan, Maren ^{[1
,2
,3
,4
,5
,6
,7
]}

Wimberger, Pauline ^{[1
,2
,3
,4
,5
,6
,7
]}

Stein, Ulrike ^{[3
,8
,9
,10
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Fac Med, Dept Gynecol & Obstet, Dresden, Germany

[2] Natl Ctr Tumor Dis NCT, Dresden, Germany

[3] German Canc Res Ctr, Heidelberg, Germany

[4] Tech Univ Dresden, Fac Med, Dresden, Germany

[5] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[6] Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany

[7] German Canc Consortium DKTK, Dresden, Germany

[8] Charite Univ Med Berlin, Expt & Clin Res Ctr, Berlin, Germany

[9] Max Delbruck Ctr Mol Med, Helmholtz Assoc, Berlin, Germany

[10] German Canc Consortium DKTK, Berlin, Germany

[11] Tech Univ Dresden, Fac Med, Med Klin & Poliklin 1, Dresden, Germany

[12] Tech Univ Dresden, Univ Hosp, Dresden, Germany

[13] ITM, DRK Blood Donor Serv, Plauen, Germany

来源：

MOLECULAR ONCOLOGY | 2019年 / 13卷 / 05期

关键词：

blood-based biomarker; MACC1; ovarian cancer; prognosis; S100A4; survival; PROGNOSTIC BIOMARKER; CONSENSUS CONFERENCE; COLORECTAL-CANCER; COLON; METASTASIS; PROGRESSION; EXPRESSION; CARCINOMA; PLASMA; MET;

D O I：

10.1002/1878-0261.12484

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis-associated in colon cancer 1 (MACC1) and S100 calcium-binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer. MACC1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by RT-qPCR and digital droplet PCR, respectively. MACC1 and S100A4 transcripts were significantly elevated in serum of ovarian cancer patients, compared to healthy controls (P = 0.024; P < 0.001). At primary diagnosis, high levels of MACC1 or S100A4 correlated with advanced FIGO stage (P = 0.042; P = 0.008), predicted suboptimal debulking surgery and indicated shorter progression-free survival (PFS; P = 0.003; P = 0.001) and overall survival (OS; P = 0.001; P = 0.002). This is the first study in ovarian cancer to propose circulating MACC1 and S100A4 transcripts as potential liquid biopsy markers.

引用

页码：1268 / 1279

页数：12

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