New insights into the roles of CHOP-induced apoptosis in ER stress

被引:407
作者
Li, Yiming [1 ]
Guo, Yunshan [2 ]
Tang, Juan [2 ]
Jiang, Jianli [2 ]
Chen, Zhinan [2 ]
机构
[1] Fourth Mil Med Univ, Brigade Undergraduates, Co 9, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Cell Engn Res Ctr, State Key Lab Canc Biol, Xian 710032, Peoples R China
基金
中国国家自然科学基金;
关键词
CHOP; ER stress; apoptosis; transcriptional factor; gene expression regulation; signal transduction; diseases; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED-PROTEIN RESPONSE; ENHANCER-BINDING-PROTEIN; CELL-DEATH; CANCER-CELLS; GENE-TRANSCRIPTION; MEDIATED APOPTOSIS; NF-Y; EXPRESSION; PATHWAY;
D O I
10.1093/abbs/gmu048
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Endoplasmic reticulum stress (ER stress) is triggered due to a loss of homeostasis in the ER, resulting in accumulation of misfolded proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of the transcription factor C/EBP homologous protein (CHOP). Although it has been proved that excessive or adverse stress to the ER triggers apoptosis, the specific mechanisms underlying these processes induced by CHOP remain unclear. By now, CHOP-induced apoptosis in ER stress has been implicated in numerous human diseases, such as neurodegenerative diseases, diabetes, ischemic diseases, tumor, and so on. In this review, we summarized the current understanding of the roles of CHOP in the development of several diseases from the laboratory to the clinic.
引用
收藏
页码:629 / 640
页数:12
相关论文
共 83 条
[1]   Endoplasmic reticulum stress response and inflammatory cytokines in type 2 diabetic nephropathy: Role of indoleamine 2,3-dioxygenase and programmed death-1 [J].
Baban, Babak ;
Liu, Jun Yao ;
Mozaffari, Mahmood S. .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2013, 94 (02) :343-351
[2]   Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response [J].
Bertolotti, A ;
Zhang, YH ;
Hendershot, LM ;
Harding, HP ;
Ron, D .
NATURE CELL BIOLOGY, 2000, 2 (06) :326-332
[3]   TISSUE-SPECIFIC EXPRESSION, DEVELOPMENTAL REGULATION, AND GENETIC-MAPPING OF THE GENE ENCODING CCAAT ENHANCER BINDING-PROTEIN [J].
BIRKENMEIER, EH ;
GWYNN, B ;
HOWARD, S ;
JERRY, J ;
GORDON, JI ;
LANDSCHULZ, WH ;
MCKNIGHT, SL .
GENES & DEVELOPMENT, 1989, 3 (08) :1146-1156
[4]   Calnexin Silencing in Mouse Neonatal Cardiomyocytes Induces Ca2+ Cycling Defects, ER Stress, and Apoptosis [J].
Bousette, Nicolas ;
Abbasi, Cynthia ;
Chis, Roxana ;
Gramolini, Anthony O. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2014, 229 (03) :374-383
[5]   Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis [J].
Bruchmann, Anja ;
Roller, Corinna ;
Walther, Tamara Vanessa ;
Schaefer, Georg ;
Lehmusvaara, Sara ;
Visakorpi, Tapio ;
Klocker, Helmut ;
Cato, Andrew C. B. ;
Maddalo, Danilo .
BMC CANCER, 2013, 13
[6]   Amino acids control mammalian gene transcription:: Activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter [J].
Bruhat, A ;
Jousse, C ;
Carraro, V ;
Reimold, AM ;
Ferrara, M ;
Fafournoux, P .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (19) :7192-7204
[7]   IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA [J].
Calfon, M ;
Zeng, HQ ;
Urano, F ;
Till, JH ;
Hubbard, SR ;
Harding, HP ;
Clark, SG ;
Ron, D .
NATURE, 2002, 415 (6867) :92-96
[8]   The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein [J].
Caspersen, C ;
Pedersen, PS ;
Treiman, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (29) :22363-22372
[9]   CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis [J].
Cazanave, Sophie C. ;
Elmi, Nafisa A. ;
Akazawa, Yuko ;
Bronk, Steven F. ;
Mott, Justin L. ;
Gores, Gregory J. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2010, 299 (01) :G236-G243
[10]   The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi [J].
Chen, X ;
Shen, J ;
Prywes, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (15) :13045-13052