Update on multiple sclerosis treatments

被引：8

作者：

Bridel, Claire ^{[1
,2
]}

Lalive, Patrice H. ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Geneva, Dept Clin Neurosci, Div Neurol, Unit Neuroimmunol & Multiple Sclerosis, CH-1211 Geneva 14, Switzerland

[2] Univ Geneva, Fac Med, Geneva, Switzerland

[3] Univ Hosp Geneva, Dept Genet & Lab Med, Div Lab Med, CH-1211 Geneva 14, Switzerland

来源：

SWISS MEDICAL WEEKLY | 2014年 / 144卷

关键词：

Multiple sclerosis; disease modifying therapies; recommendations; fingolimod; interferon beta; glatiramer acetate; teriflunomide; dimethyl fumarate; PLACEBO-CONTROLLED TRIAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; INTERFERON BETA-1A THERAPY; CONTROLLED PHASE-3 TRIAL; DOUBLE-BLIND; INFLUENZA VACCINE; IMMUNE-RESPONSE; ORAL LAQUINIMOD; INTRAMUSCULAR INTERFERON; ALEMTUZUMAB TREATMENT;

D O I：

10.4414/smw.2014.14012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Relapsing-remitting multiple sclerosis (RRMS) management has dramatically changed over the past decade. New drugs have arrived on the market, allowing for more individualised treatment selection. However, this diversity has increased the complexity of RRMS patient follow-up. In this review, we provide summarised information about treatment efficacy, potential side-effects, follow-up recommendations, vaccinations, and pregnancy safety issues for all currently available disease modifying therapies and those awaiting approval.

引用

页数：7

共 75 条

[1] Teriflunomide effect on immune response to influenza vaccine in patients with multiple sclerosis [J].

Bar-Or, Amit ;

Freedman, Mark S. ;

Kremenchutzky, Marcelo ;

Menguy-Vacheron, Francoise ;

Bauer, Deborah ;

Jodl, Stefan ;

Truffinet, Philippe ;

Benamor, Myriam ;

Chambers, Scott ;

O'Connor, Paul W. .

NEUROLOGY, 2013, 81 (06) :552-558

[2] Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy [J].

Barnett, M. H. ;

Prineas, J. W. ;

Buckland, M. E. ;

Parratt, J. D. E. ;

Pollard, J. D. .

MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (01) :108-112

[3] The immune modulator FTY720 targets sphingosine 1-phosphate receptors [J].

Brinkmann, V ;

Davis, MD ;

Heise, CE ;

Albert, R ;

Cottens, S ;

Hof, R ;

Bruns, C ;

Prieschl, E ;

Baumruker, T ;

Hiestand, P ;

Foster, CA ;

Zollinger, M ;

Lynch, KR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21453-21457

[4] Insight into the mechanism of laquinimod action [J].

Brueck, W. ;

Wegner, C. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2011, 306 (1-2) :173-179

[5] MULTIPLE SCLEROSIS Oral laquinimod for MS-bringing the brain into focus [J].

Brueck, Wolfgang ;

Vollmer, Timothy .

NATURE REVIEWS NEUROLOGY, 2013, 9 (12) :664-665

[6] The incidence and significance of anti-natalizumab antibodies -: Results from AFFIRM and SENTINEL [J].

Calabresi, P. A. ;

Giovannoni, G. ;

Confavreux, C. ;

Galetta, S. L. ;

Havrdova, E. ;

Hutchinson, M. ;

Kappos, L. ;

Miller, D. H. ;

O'Connor, P. W. ;

Phillips, J. T. ;

Polman, C. H. ;

Radue, E. -W. ;

Rudick, R. A. ;

Stuart, W. H. ;

Lublin, F. D. ;

Wajgt, A. ;

Weinstock-Guttman, B. ;

Wynn, D. R. ;

Lynn, F. ;

Panzara, M. A. ;

Macdonell, R. ;

Hughes, A. ;

Taylor, I. ;

Lee, Y. C. ;

Ma, H. ;

King, J. ;

Kilpatrick, T. ;

Butzkueven, H. ;

Marriott, M. ;

Pollard, J. ;

Spring, P. ;

Spies, J. ;

Barnett, M. ;

Dehaene, I. ;

Vanopdenbosch, L. ;

D'Hooghe, M. ;

Van Zandijcke, M. ;

Derijck, O. ;

Seeldrayers, P. ;

Jacquy, J. ;

Piette, T. ;

De Cock, C. ;

Medaer, R. ;

Soors, P. ;

Vanroose, E. ;

Vanderhoven, L. ;

Nagels, G. ;

Dubois, B. ;

Deville, M. -C. ;

D'Haene, R. .

NEUROLOGY, 2007, 69 (14) :1391-1403

[7] LEFLUNOMIDE INTERFERES WITH PYRIMIDINE NUCLEOTIDE BIOSYNTHESIS [J].

CHERWINSKI, HM ;

BYARS, N ;

BALLARON, SJ ;

NAKANO, GM ;

YOUNG, JM ;

RANSOM, JT .

INFLAMMATION RESEARCH, 1995, 44 (08) :317-322

[8] Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial [J].

Cohen, Jeffrey A. ;

Coles, Alasdair J. ;

Arnold, Douglas L. ;

Confavreux, Christian ;

Fox, Edward J. ;

Hartung, Hans-Peter ;

Havrdova, Eva ;

Selmaj, Krzysztof W. ;

Weiner, Howard L. ;

Fisher, Elizabeth ;

Brinar, Vesna V. ;

Giovannoni, Gavin ;

Stojanovic, Miroslav ;

Ertik, Bella I. ;

Lake, Stephen L. ;

Margolin, David H. ;

Panzara, Michael A. ;

Compston, D. Alastair S. .

LANCET, 2012, 380 (9856) :1819-1828

[9] Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis [J].

Cohen, Jeffrey A. ;

Barkhof, Frederik ;

Comi, Giancarlo ;

Hartung, Hans-Peter ;

Khatri, Bhupendra O. ;

Montalban, Xavier ;

Pelletier, Jean ;

Capra, Ruggero ;

Gallo, Paolo ;

Izquierdo, Guillermo ;

Tiel-Wilck, Klaus ;

de Vera, Ana ;

Jin, James ;

Stites, Tracy ;

Wu, Stacy ;

Aradhye, Shreeram ;

Kappos, Ludwig .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (05) :402-415

[10] Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis [J].

Coles, AJ ;

Wing, N ;

Smith, S ;

Coraddu, F ;

Greer, S ;

Taylor, C ;

Weetman, A ;

Hale, G ;

Chatterjee, VK ;

Waldmann, H ;

Compston, A .

LANCET, 1999, 354 (9191) :1691-1695

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