Delayed hypersensitivity to flurbiprofen

被引：14
作者：
Romano, A
Pietrantonio, F
机构：
[1] Ist. di Medicina Interna e Geriatria, Univ. Cattolica del Sacro Cuore, Rome
[2] Ist. di Medicina Interna e Geriatria, Univ. Cattolica del Sacro Cuore, 00168 Rome, Largo A, Gemelli
来源：
JOURNAL OF INTERNAL MEDICINE | 1997年 / 241卷 / 01期
关键词：
flurbiprofen; skin adverse effects; delayed hypersensitivity; drug reactions; patch tests;
D O I：
10.1046/j.1365-2796.1997.64887000.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immune-mediated reactions to nonsteroidal antiinflammatory drugs (NSAIDs) are unusual, and true allergy to the drug flurbiprofen has never been documented. We observed a patient who developed a maculopapular rash 48 h after beginning oral therapy with this drug, and 2 days later, angioedema and hypotension. Patch tests with flurbiprofen were positive 48 and 72 h after application. The clinical and allergologic features of this case strongly suggest type IV hypersensitivity. Patch testing with NSAIDs is useful for confirming clinical diagnoses of delayed hypersensitivity to these drugs.
引用
收藏
页码：81 / 83
页数：3
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