Differential regulation of osteoadherin (OSAD) by TGF-β1 and BMP-2

被引：27
|
作者：
Rehn, Anders P.
Chalk, Alistair M.
Wendel, Mikael
机构：
[1] Karolinska Inst, Ctr Oral Biol, S-14104 Huddinge, Sweden
[2] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 349卷 / 03期
关键词：
osteoadherin; TGF-beta; 1; BMP-2; promoter; osteoblast; transcription factor binding site;
D O I：
10.1016/j.bbrc.2006.08.133
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Osteoadherin (OSAD) is a member of the small leucine rich-repeat proteoglycan (SLRP) family. SLRPs are normally found in extracellular matrices, but OSAD is the only member restricted to mineralized tissues. We investigated the promoter region of OSAD by in silico analysis and found that the proximal promoter region contains sites for Smad-3, Smad-4, and AP-1. All are effectors of TGF-beta family signalling. We tested sensitivity of the promoter to the two TGF-beta family members TGF-beta 1 and BMP-2. We found TGF-beta 1 to down regulate OSAD, while BMP-2 up regulates OSAD. As a consequence of how OSAD is regulated by TGF-beta 1 and BMP-2 and its temporal expression pattern in osteoblasts and bone development, we can conclude OSAD as an early marker for terminally differentiated matrix producing osteoblasts. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1057 / 1064
页数：8
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