History of Psychopharmacology

被引：48

作者：

Braslow, Joel T. ^{[1
,2
]}

Marder, Stephen R. ^{[1
,3
]}

机构：

[1] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Hist, Los Angeles, CA 90095 USA

[3] Vet Adm Desert Pacific Mental Illness Res Educ &, Los Angeles, CA 90073 USA

来源：

ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 15 | 2019年 / 15卷

关键词：

psychopharmacology; history; antipsychotics; antidepressants; mental illness; treatment; STATE-MENTAL-HOSPITALS; ANTIPSYCHOTIC-DRUGS; DOPAMINE HYPOTHESIS; PSYCHOTROPIC-DRUGS; SCHIZOPHRENIA; RESERPINE; CHLORPROMAZINE; CLOZAPINE; SCALE; DEINSTITUTIONALIZATION;

D O I：

10.1146/annurev-clinpsy-050718-095514

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

We live in an age of psychopharmacology. One in six persons currently takes a psychotropic drug. These drugs have profoundly shaped our scientific and cultural understanding of psychiatric disease. By way of a historical review, we try to make sense of psychiatry's dependency on psychiatric drugs in the care of patients. Modern psychopharmacology began in 1950 with the synthesis of chlorpromazine. Over the course of the next 50 years, the psychiatric understanding and treatment of mental illness radically changed. Psychotropic drugs played a major part in these changes as state hospitals closed and psychotherapy gave way to drug prescriptions. Our review suggests that the success of psychopharmacology was not the consequence of increasingly more effective drugs for discrete psychiatric diseases. Instead, a complex mix of political economic realities, pharmaceutical marketing, basic science advances, and changes in the mental health-care system have led to our current infatuation with psychopharmacology.

引用

页码：25 / 50

页数：26

共 103 条

[11] EFFECT OF PSYCHOTROPIC DRUGS ON UPTAKE OF H3-NOREPINEPHRINE BY TISSUES [J].