Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

被引:121
作者
Dotto, G. Paolo [1 ,2 ]
机构
[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland
[2] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Boston, MA 02114 USA
基金
瑞士国家科学基金会;
关键词
EPIGENETIC FIELD; PROSTATE-CANCER; GASTRIC-CANCER; BREAST-CANCER; SKIN CARCINOGENESIS; GENOMIC INSTABILITY; GENETIC ALTERATIONS; ALLELIC IMBALANCE; CLONAL EVOLUTION; DNA METHYLATION;
D O I
10.1172/JCI72589
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
It is increasingly evident that cancer results from altered organ homeostasis rather than from deregulated control of single cells or groups of cells. This applies especially to epithelial cancer, the most common form of human solid tumors and a major cause of cancer lethality. In the vast majority of cases, in situ epithelial cancer lesions do not progress into malignancy, even if they harbor many of the genetic changes found in invasive and metastatic tumors. While changes in tumor stroma are frequently viewed as secondary to changes in the epithelium, recent evidence indicates that they can play a primary role in both cancer progression and initiation. These processes may explain the phenomenon of field cancerization, i.e., the occurrence of multifocal and recurrent epithelial tumors that are preceded by and associated with widespread changes of surrounding tissue or organ "fields."
引用
收藏
页码:1446 / 1453
页数:8
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