Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

被引：166

作者：

Kawashima, Tadaomi ^{[1
,2
]}

Kosaka, Akemi ^{[1
]}

Yan, Huimin ^{[1
,3
]}

Guo, Zijin ^{[4
]}

Uchiyama, Ryosuke ^{[7
]}

Fukui, Ryutaro ^{[8
]}

Kaneko, Daisuke ^{[2
]}

Kumagai, Yutaro ^{[10
]}

You, Dong-Ju ^{[11
]}

Carreras, Joaquim ^{[1
]}

Uematsu, Satoshi ^{[9
]}

Jang, Myoung Ho ^{[11
,14
]}

Takeuchi, Osamu ^{[10
,15
]}

Kaisho, Tsuneyasu ^{[5
,12
]}

Akira, Shizuo ^{[10
]}

Miyake, Kensuke ^{[8
]}

Tsutsui, Hiroko ^{[7
]}

Saito, Takashi ^{[6
,13
]}

Nishimura, Ikuko ^{[2
]}

Tsuji, Noriko M. ^{[1
,4
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Tsukuba, Ibaraki 3058566, Japan

[2] Kikkoman Foods Inc, Div Res & Dev, Noda, Chiba 2780037, Japan

[3] Fifth Hosp Shijiazhuang, Shijiazhuang 050021, Hebei, Peoples R China

[4] RIKEN, Res Ctr Allergy & Immunol, Lab Mucosal Immune Tolerance, Yokohama, Kanagawa 2300045, Japan

[5] RIKEN, Res Ctr Allergy & Immunol, Lab Host Def, Yokohama, Kanagawa 2300045, Japan

[6] RIKEN, Res Ctr Allergy & Immunol, Lab Cell Signaling, Yokohama, Kanagawa 2300045, Japan

[7] Hyogo Coll Med, Dept Microbiol, Nishinomiya, Hyogo 6638501, Japan

[8] Univ Tokyo, Inst Med Sci, Int Res & Dev Ctr Mucosal Vaccine, Div Infect Genet, Shiroganedai, Tokyo 1088639, Japan

[9] Univ Tokyo, Inst Med Sci, Int Res & Dev Ctr Mucosal Vaccine, Div Innate Immune Regulat, Shiroganedai, Tokyo 1088639, Japan

[10] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Host Def, Suita, Osaka 5650871, Japan

[11] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Gastrointestinal Immunol, Suita, Osaka 5650871, Japan

[12] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Immune Regulat, Suita, Osaka 5650871, Japan

[13] Osaka Univ, WPI Immunol Frontier Res Ctr, Lab Cell Signaling, Suita, Osaka 5650871, Japan

[14] Pohang Univ Sci & Technol POSTECH, Div Integrat Biosci & Biotechnol, Pohang 790784, South Korea

[15] Kyoto Univ, Inst Virus Res, Lab Infect & Prevent, Sakyo Ku, Kyoto 6068507, Japan

来源：

IMMUNITY | 2013年 / 38卷 / 06期

关键词：

TOLL-LIKE RECEPTOR-3; INNATE IMMUNE RECOGNITION; I INTERFERON; DENDRITIC CELLS; MESSENGER-RNA; T-CELLS; LACTOBACILLUS; ANTIGEN; COLONIZATION; INDUCTION;

D O I：

10.1016/j.immuni.2013.02.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The small intestine harbors a substantial number of commensal bacteria and is sporadically invaded by pathogens, but the response to these microorganisms is fundamentally different. We identified a discriminatory sensor by using Toll-like receptor 3 (TLR3). Double-stranded RNA (dsRNA) of one major commensal species, lactic acid bacteria (LAB), triggered interferon-beta (IFN-beta) production, which protected mice from experimental colitis. The LABinduced IFN-beta response was diminished by dsRNA digestion and treatment with endosomal inhibitors. Pathogenic bacteria contained less dsRNA and induced much less IFN-beta than LAB, and dsRNA was not involved in pathogen-induced IFN-beta induction. These results identify TLR3 as a sensor to small intestinal commensal bacteria and suggest that dsRNA in commensal bacteria contributes to anti-inflammatory and protective immune responses.

引用

页码：1187 / 1197

页数：11

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